Anti-Ionotropic Glutamate receptor 2 (phospho S880)抗体(ab52180)
Key features and details
- Rabbit polyclonal to Ionotropic Glutamate receptor 2 (phospho S880)
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-Ionotropic Glutamate receptor 2 (phospho S880)抗体
参阅全部 Ionotropic Glutamate receptor 2 一抗 -
描述
兔多克隆抗体to Ionotropic Glutamate receptor 2 (phospho S880) -
宿主
Rabbit -
特异性
Detects endogenous levels of Glutamate receptor 2 only when phosphorylated at serine 880. -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide corresponding to Human Ionotropic Glutamate receptor 2 aa 800-900 (phospho S880).
Database link: P42262 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab52180于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use at an assay dependent concentration.
|
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| WB |
1/500 - 1/1000. Detects a band of approximately 99 kDa (predicted molecular weight: 99 kDa).
|
| 说明 |
|---|
|
IHC-P
Use at an assay dependent concentration. |
|
WB
1/500 - 1/1000. Detects a band of approximately 99 kDa (predicted molecular weight: 99 kDa). |
靶标
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功能
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. -
序列相似性
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily. -
翻译后修饰
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. -
细胞定位
Cell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. - Information by UniProt
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数据库链接
- Entrez Gene: 2891 Human
- Entrez Gene: 14800 Mouse
- Omim: 138247 Human
- SwissProt: P42262 Human
- SwissProt: P23819 Mouse
- Unigene: 32763 Human
- Unigene: 220224 Mouse
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别名
- AMPA 2 antibody
- AMPA selective glutamate receptor 2 antibody
- AMPA-selective glutamate receptor 2 antibody
see all
图片
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Western blot - Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody (ab52180)All lanes : Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody (ab52180) at 1/500 dilution
Lane 1 : extracts from mouse brain
Lane 2 : extracts from mouse brain with blocking phosphopeptide
Predicted band size: 99 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody (ab52180)Ab52180 at 1/50 dilution staining Human brain tissue, with and without blocking peptide; paraffin embedded.
数据表及文件
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SDS download
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Datasheet download
文献 (20)
ab52180 被引用在 20 文献中.
- Mingardi J et al. Functional and Molecular Changes in the Prefrontal Cortex of the Chronic Mild Stress Rat Model of Depression and Modulation by Acute Ketamine. Int J Mol Sci 24:N/A (2023). PubMed: 37445990
- Zhang Y & Jeske NA A-kinase anchoring protein 79/150 coordinates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor sensitization in sensory neurons. Mol Pain 19:17448069231222406 (2023). PubMed: 38073552
- Forti L et al. Dopamine-Dependent Ketamine Modulation of Glutamatergic Synaptic Plasticity in the Prelimbic Cortex of Adult Rats Exposed to Acute Stress. Int J Mol Sci 24:N/A (2023). PubMed: 37240064
- Lauretti E et al. Extra virgin olive oil improves synaptic activity, short-term plasticity, memory, and neuropathology in a tauopathy model. Aging Cell 19:e13076 (2020). PubMed: 31762202
- Pensalfini A et al. Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell Rep 33:108420 (2020). PubMed: 33238112