Anti-Interferon gamma抗体[B-B1] - BSA and Azide free (ab47343)
Key features and details
- Mouse monoclonal [B-B1] to Interferon gamma - BSA and Azide free
- Suitable for: Blocking, Flow Cyt
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-Interferon gamma抗体[B-B1] - BSA and Azide free
参阅全部 Interferon gamma 一抗 -
描述
小鼠单克隆抗体[B-B1] to Interferon gamma - BSA and Azide free -
宿主
Mouse -
特异性
ab47343 recognises both natural and recombinant Human Interferon gamma.
It inhibits Interferon gamma induced proliferation.
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经测试应用
适用于: Blocking, Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length Human Interferon gamma.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Constituent: 100% PBS
Sterile-filtered through 0.22 µm. Carrier and preservative free -
无载体
是 -
Concentration information loading...
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纯度
Ion Exchange Chromatography -
纯化说明
Sterile filtered through 0.22 µm and treated to remove endotoxins. Carrier and preservative free. -
克隆
单克隆 -
克隆编号
B-B1 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab47343于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Blocking |
Use at an assay dependent concentration.
ab47343 blocks Interferon gamma-induced proliferation. |
|
Flow Cyt |
Use at an assay dependent concentration.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
说明 |
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Blocking
Use at an assay dependent concentration. ab47343 blocks Interferon gamma-induced proliferation. |
Flow Cyt
Use at an assay dependent concentration. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. -
组织特异性
Released primarily from activated T lymphocytes. -
疾病相关
In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis. -
序列相似性
Belongs to the type II (or gamma) interferon family. -
翻译后修饰
Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 3458 Human
- Omim: 147570 Human
- SwissProt: P01579 Human
- Unigene: 856 Human
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别名
- IF 1 antibody
- IFG antibody
- IFI antibody
see all
图片
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Flow cytometry analysis of activated lymphocytes labeling B-B1 with ab47343. The dotted line represents the IgG1 isotype control.
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Flow cytometry analysis of non-activated lymphocytes labeling B-B1 with ab47343. The dotted line represents the IgG1 isotype control.
数据表及文件
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Datasheet download
文献 (0)
ab47343 尚未被引用在任何文献中。