Anti-Interferon alpha/beta receptor 1抗体(ab62693)
Key features and details
- Rabbit polyclonal to Interferon alpha/beta receptor 1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Interferon alpha/beta receptor 1抗体
参阅全部 Interferon alpha/beta receptor 1 一抗 -
描述
兔多克隆抗体to Interferon alpha/beta receptor 1 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human Interferon alpha/beta receptor 1.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Without Mg2+ and Ca2+ -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
ab62693 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab62693于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/50 - 1/100.
|
|
| IF |
1/100 - 1/500.
|
| 说明 |
|---|
|
IHC-P
1/50 - 1/100. |
|
IF
1/100 - 1/500. |
靶标
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功能
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. -
组织特异性
IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. -
序列相似性
Belongs to the type II cytokine receptor family.
Contains 3 fibronectin type-III domains. -
翻译后修饰
Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3454 Human
- Omim: 107450 Human
- SwissProt: P17181 Human
- Unigene: 529400 Human
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别名
- Alpha type antiviral protein antibody
- Antiviral protein, alpha-type antibody
- Antiviral protein, beta-type antibody
see all
图片
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Immunofluorescence - Anti-Interferon alpha/beta receptor 1 antibody (ab62693)
Immunofluorescent analysis of HepG2 cells labeling interferon alpha/beta receptor with ab62693. The image on the right is blocked with the synthesized peptide prior to imunnoflurescent labeling.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Interferon alpha/beta receptor 1 antibody (ab62693)ab62693 at 1/50 dilution staining Interferon alpha/beta receptor 1 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab62693 被引用在 5 文献中.
- Simeone E et al. A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon (VEMUPLINT) in advanced melanoma patients harboring the V600BRAF mutation. J Transl Med 19:17 (2021). PubMed: 33407577
- Liu Z et al. Efficient mutagenesis targeting the IFNAR1 gene in mice using a combination of Cas9 protein and dual gRNAs. Am J Transl Res 13:12094-12106 (2021). PubMed: 34786147
- Hayashi Y et al. Cochlear supporting cells function as macrophage-like cells and protect audiosensory receptor hair cells from pathogens. Sci Rep 10:6740 (2020). PubMed: 32317718
- Pringle S et al. Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's Syndrome. Arthritis Rheumatol 71:133-142 (2019). PubMed: 29984480
- Sartoris S et al. Efficacy assessment of interferon-alpha-engineered mesenchymal stromal cells in a mouse plasmacytoma model. Stem Cells Dev 20:709-19 (2011). IHC-Fr ; Mouse . PubMed: 20695752