AB29043

Anti-Integrin beta 4 (phospho Y1494)抗体

Name: Integrin beta 4(磷酸化Y1494)抗体 (ab29043)| Abcam中文官网
Brand: Abcam Limited
SKU: AB29043
Price: 4606 CNY
Availability: InStock

Anti-Integrin beta 4 (phospho Y1494) antibody

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(2 Publications)

Rabbit Polyclonal Integrin beta 4 phospho Y1494 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Integrin beta-4 phospho Y1494 conjugated to Keyhole Limpet Haemocyanin.

查看别名

CD104, Integrin beta-4, GP150, ITGB4

1 Images

Unknown

Western blot - Anti-Integrin beta 4 (phospho Y1494) antibody (AB29043)

All lanes:

Western blot - Anti-Integrin beta 4 (phospho Y1494) antibody (ab29043)

Lane 1:

A431 (25 µg/lane) serum starved overnight

Lane 2:

A431 (25 µg/lane) serum treated with pervanadate (1 mM) for 30 min with absence of peptide

Lane 3:

A431 (25 µg/lane) serum treated with pervanadate (1 mM) for 30 min with presence of phospho-integrin-beta4 (Tyr-1494) peptide

Lane 4:

A431 (25 µg/lane) serum treated with pervanadate (1 mM) for 30 min with presence of phospho-integrin-beta4 (Tyr-1526) peptide

Predicted band size: 202 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human Integrin beta-4 phospho Y1494 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P16144

特异性

ab29043 recognises all three isoforms of Integrin beta 4 phosphorilated at tyrosine 1494 (beta 4A, beta 4B and beta 4C).

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p>Block the membrane in 5% BSA (fraction V).</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab29043 was cross adsorbed to phospho tyrosine coupled to agarose prior to immunogen affinity purification (without carrier protein).

存储溶液

Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Integrin beta 4 also known as ITGB4 integrin ß4 or integrine beta 4 is a transmembrane protein that mechanically links the extracellular matrix to the intracellular cytoskeleton. This protein has a molecular mass of approximately 205 kDa. Integrin beta 4 primarily expresses in epithelial cells particularly those forming stratified and transitional epithelia. It partners with alpha 6 integrin to form the alpha 6 beta 4 integrin complex which plays a significant role in the formation and maintenance of hemidesmosomes.

Biological function summary

Integrin beta 4 is important for anchoring epithelial cells to the basement membrane stabilizing cell layers in tissues. It interacts with intermediate filaments through specific cytoplasmic proteins. The integrin beta 4 complex ensures structural integrity essential for maintaining the skin and mucosal barriers. Integrations with proteins like M126 are essential for strengthening these interactions safeguarding cellular stability and promoting wound healing.

Pathways

Integrin beta 4 is embedded in key signaling pathways that influence cell adhesion and migration. It participates prominently in the PI3K/AKT and RAS pathway collaborations facilitating signal transduction essential for cell growth and survival. Through these pathways integrin beta 4 interacts with proteins like IS200BPIRG1A linking extracellular cues to internal cellular responses.

Integrin beta 4 has associations with epidermolysis bullosa and various cancers. In epidermolysis bullosa mutations in integrin beta 4 impair hemidesmosomal function leading to skin fragility. In cancer integrin beta 4 overexpression or mislocalization contributes to tumor progression affecting cell invasion and metastasis. Its interactions with IS200BPIAG1A or related pathways highlight the protein’s influence on carcinogenic processes and potential as a therapeutic target.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6 : ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed : 20682778). ITGA6 : ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed : 22351760). ITGA6 : ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed : 28873464).

See full target information Integrin beta-4 phospho Y1494

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 25:253 PubMed40615856

2025

STIM1 signaling modulates invasive phenotypic plasticity by regulating calpain-dependent cleavage of integrin-β4 in nasopharyngeal carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Weiming Deng,Wenlin Huang,Yujuan Huang,Lihong Huang,Linsong Ye,Fei Liu,Min Li,Jingjin Weng,Qian He,Jinyan Zhang,Shenhong Qu,Jiazhang Wei

Oncotarget 7:16282-96 PubMed26918348

2016

A small molecule induces integrin β4 nuclear translocation and apoptosis selectively in cancer cells with high expression of integrin β4.

Applications

Unspecified application

Species

Unspecified reactive species

Shu Yan Liu,Di Ge,Li Na Chen,Jing Zhao,Le Su,Shang Li Zhang,Jun Ying Miao,Bao Xiang Zhao

View all publications

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Abcam Product Promise

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Anti-Integrin beta 4 (phospho Y1494)抗体

Anti-Integrin beta 4 (phospho Y1494) antibody

Western blot - Anti-Integrin beta 4 (phospho Y1494) antibody (AB29043)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性