AB110167

Anti-Integrin beta 4抗体[439-9B]

Name: Integrin beta 4抗体[439-9B] (ab110167)| Abcam中文官网
Brand: Abcam Limited
SKU: AB110167
Price: 4497 CNY
Availability: InStock

Anti-Integrin beta 4 antibody [439-9B]

(2 Reviews)

(13 Publications)

Rat Monoclonal Integrin beta 4 antibody. Suitable for IHC-P, Flow Cyt and reacts with Human samples. Cited in 13 publications.

查看别名

CD104, Integrin beta-4, GP150, ITGB4

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin beta 4 antibody [439-9B] (AB110167)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin beta 4 antibody [439-9B] (AB110167)

ab110167 at 20 μg/ml staining integrin beta 4 in Formalin-Fixed, Paraffin-Embedded Human Pancreas (ab29816). Sections were incubated with a biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin beta 4 antibody [439-9B] (AB110167)

ab110167 at 20 μg/ml staining integrin beta 4 in Formalin-Fixed, Paraffin-Embedded Human Placenta. Sections were incubated with a biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Flow Cytometry - Anti-Integrin beta 4 antibody [439-9B] (AB110167)

Flow Cyt

Unknown

Flow Cytometry - Anti-Integrin beta 4 antibody [439-9B] (AB110167)

Staining of the A549 cell line with 0.5 ug of Rat IgG2b Isotype Control (ab98984) (blue histogram) or 0.5 ug of ab110167 (purple histogram) followed by Biotin Anti-Rat IgG and Sav-PE. Total viable cells were used for analysis.

不同偶联物与剂型 (1)

Biotin

Biotin Anti-Integrin beta 4 antibody [439-9B]

关键信息

宿主种属

Rat

克隆

Monoclonal

克隆号

439-9B

亚型

IgG2b

不含载体蛋白

反应种属

Human

应用

IHC-P, Flow Cyt

applications

特异性

Recognizes human Integrin beta-4, a 202 kDa subunit that associates with integrin alpha 6 (CD49f), thereby forming the laminin receptor. Multiple splice variants have been identified. It is used as a surface staining antibody.

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "20 µg/mL", "IHCP-species-notes": "", "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1 µg for 10^5-10^8 Cells", "FlowCyt-species-notes": "in 100 μl.ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody." } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification

存储溶液

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Integrin beta 4 also known as ITGB4 integrin ß4 or integrine beta 4 is a transmembrane protein that mechanically links the extracellular matrix to the intracellular cytoskeleton. This protein has a molecular mass of approximately 205 kDa. Integrin beta 4 primarily expresses in epithelial cells particularly those forming stratified and transitional epithelia. It partners with alpha 6 integrin to form the alpha 6 beta 4 integrin complex which plays a significant role in the formation and maintenance of hemidesmosomes.

Biological function summary

Integrin beta 4 is important for anchoring epithelial cells to the basement membrane stabilizing cell layers in tissues. It interacts with intermediate filaments through specific cytoplasmic proteins. The integrin beta 4 complex ensures structural integrity essential for maintaining the skin and mucosal barriers. Integrations with proteins like M126 are essential for strengthening these interactions safeguarding cellular stability and promoting wound healing.

Pathways

Integrin beta 4 is embedded in key signaling pathways that influence cell adhesion and migration. It participates prominently in the PI3K/AKT and RAS pathway collaborations facilitating signal transduction essential for cell growth and survival. Through these pathways integrin beta 4 interacts with proteins like IS200BPIRG1A linking extracellular cues to internal cellular responses.

Integrin beta 4 has associations with epidermolysis bullosa and various cancers. In epidermolysis bullosa mutations in integrin beta 4 impair hemidesmosomal function leading to skin fragility. In cancer integrin beta 4 overexpression or mislocalization contributes to tumor progression affecting cell invasion and metastasis. Its interactions with IS200BPIAG1A or related pathways highlight the protein’s influence on carcinogenic processes and potential as a therapeutic target.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6 : ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed : 20682778). ITGA6 : ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed : 22351760). ITGA6 : ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed : 28873464).

See full target information ITGB4

style

left-column

文献 (13)

Recent publications for all applications. Explore the full list and refine your search

Cancer research communications 5:1319-1331 PubMed40728119

2025

Collagen XVII Promotes Pancreatic Ductal Adenocarcinoma Tumor Growth through Regulation of PIK3R5.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas Hank,Annie Li,Louisa Bolm,Marta Sandini,Taisuke Baba,Natalie Petruch,Julia Strässer,Kenzui Taniue,Jon M Harrison,Mari Mino-Kenudson,David T Ting,Keith D Lillemoe,Andrew L Warshaw,Carlos Fernández-Del Castillo,Kim C Honselmann,Andrew S Liss

Pediatric surgery international 40:6 PubMed37999863

2023

Generation of human gastric assembloids from primary fetal organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Giada Benedetti,Brendan C Jones,Francesca Sgualdino,Paolo De Coppi,Giovanni Giuseppe Giobbe

Journal of biomedical materials research. Part B, Applied biomaterials 110:2533-2541 PubMed35730701

2022

Epithelial cell attachment and adhesion protein expression on novel in sol TiO coated zirconia and titanium alloy surfaces.

Applications

Unspecified application

Species

Unspecified reactive species

Sini Riivari,Elisa Närvä,Ilkka Kangasniemi,Jaana Willberg,Timo Närhi

Molecular cancer research : MCR 20:1305-1319 PubMed35394541

2022

KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Seo-Hyun Choi,Jin K Kim,Chin-Tung Chen,Chao Wu,Michael R Marco,Francisco M Barriga,Kevin O'Rourke,Raphael Pelossof,Xuan Qu,Qing Chang,Elisa de Stanchina,Jinru Shia,J Joshua Smith,Francisco Sanchez-Vega,Julio Garcia-Aguilar

Science advances 8:eabj9513 PubMed34995107

2022

O-linked α2,3 sialylation defines stem cell populations in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Melanie R Walker,Hira Lal Goel,Dimpi Mukhopadhyay,Peter Chhoy,Emmet R Karner,Jennifer L Clark,Haibo Liu,Rui Li,Julie Lihua Zhu,Shuhui Chen,Lara K Mahal,Barbara A Bensing,Arthur M Mercurio

Biochemical pharmacology 192:114692 PubMed34298004

2021

MicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Uttom Kumar,Yunhui Hu,Nahal Masrour,Marcos Castellanos-Uribe,Alison Harrod,Sean T May,Simak Ali,Valerie Speirs,R Charles Coombes,Ernesto Yagüe

Nature biomedical engineering 4:901-915 PubMed32572195

2020

Intravital three-dimensional bioprinting.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Urciuolo,Ilaria Poli,Luca Brandolino,Paolo Raffa,Valentina Scattolini,Cecilia Laterza,Giovanni G Giobbe,Elisa Zambaiti,Giulia Selmin,Michael Magnussen,Laura Brigo,Paolo De Coppi,Stefano Salmaso,Monica Giomo,Nicola Elvassore

Oncogene 39:399-413 PubMed31477840

2019

Centrosome loss results in an unstable genome and malignant prostate tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Mengdie Wang,Raymond B Nagle,Beatrice S Knudsen,Anne E Cress,Gregory C Rogers

Molecular biology of the cell 30:838-850 PubMed30865564

2019

Integrin α6β4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions.

Applications

Unspecified application

Species

Unspecified reactive species

Mengdie Wang,James P Hinton,Jaime M C Gard,Joe G N Garcia,Beatrice S Knudsen,Raymond B Nagle,Anne E Cress

The Journal of cell biology 216:4287-4297 PubMed28972104

2017

The α6β4 integrin promotes resistance to ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Caitlin W Brown,John J Amante,Hira Lal Goel,Arthur M Mercurio

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Integrin beta 4抗体[439-9B]