Anti-Integrin alpha V抗体(ab117611)
Key features and details
- Rabbit polyclonal to Integrin alpha V
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Integrin alpha V抗体
参阅全部 Integrin alpha V 一抗 -
描述
兔多克隆抗体to Integrin alpha V -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide conjugated to KLH corresponding to C terminal residues of Human Integrin alpha V (NP_002201.1).
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阳性对照
- Human Placenta and Thyroid tissues; A549 cell extracts, treated with etoposide.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine)
PBS (without Mg2+, Ca2+) -
Concentration information loading... -
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab117611于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/1000. Predicted molecular weight: 116 kDa.
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| IHC-P | (1) |
Use a concentration of 5 µg/ml.
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| 说明 |
|---|
|
WB
1/500 - 1/1000. Predicted molecular weight: 116 kDa. |
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IHC-P
Use a concentration of 5 µg/ml. |
靶标
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功能
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. -
序列相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3685 Human
- Omim: 193210 Human
- SwissProt: P06756 Human
- Unigene: 436873 Human
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别名
- antigen identified by monoclonal antibody L230 antibody
- CD 51 antibody
- CD51 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha V antibody (ab117611)ab117611, at 5 µg/ml, staining Integrin alpha V in Formalin-fixed, Paraffin-embedded Human Thyroid tissue by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin alpha V antibody (ab117611)ab117611, at 5 µg/ml, staining Integrin alpha V in Formalin-fixed, Paraffin-embedded Human Placenta tissue by Immunohistochemistry. -
Western blot - Anti-Integrin alpha V antibody (ab117611)All lanes : Anti-Integrin alpha V antibody (ab117611) at 1/500 dilution
Lane 1 : A549 cell extracts, treated with etoposide 25uM 1hr
Lane 2 : A549 cell extracts, treated with etoposide 25uM 1h with synthetic peptide
Predicted band size: 116 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab117611 被引用在 5 文献中.
- Finney AC et al. EphA2 signaling within integrin adhesions regulates fibrillar adhesion elongation and fibronectin deposition. Matrix Biol 103-104:1-21 (2021). PubMed: 34537369
- Ji Q et al. Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation. Nat Commun 11:1211 (2020). PubMed: 32139701
- Spinelli C et al. Molecular subtypes and differentiation programmes of glioma stem cells as determinants of extracellular vesicle profiles and endothelial cell-stimulating activities. J Extracell Vesicles 7:1490144 (2018). PubMed: 30034643
- Vogt D et al. Premacular membranes in tissue culture. Graefes Arch Clin Exp Ophthalmol N/A:N/A (2018). PubMed: 29931427
- Hoshino A et al. Tumour exosome integrins determine organotropic metastasis. Nature 527:329-35 (2015). WB ; Human . PubMed: 26524530