Anti-Insulin抗体[K36aC10] (ab6995)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Insulin antibody [K36aC10] (ab6995)](https://www.abcam.cn/ps/products/6/ab6995/Images/ab6995-411483-AntiInsulin-antibody.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Insulin antibody [K36aC10] (ab6995)")
Key features and details
- Mouse monoclonal [K36aC10] to Insulin
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-Insulin抗体[K36aC10]
参阅全部 Insulin 一抗 -
描述
小鼠单克隆抗体[K36aC10] to Insulin -
宿主
Mouse -
特异性
The antibody exhibits cross-reactivity with human proinsulin. This antibody recognizes purified insulin from the pancreas of human, bovine, horse, sheep, and proinsulin from human. Cross reaction has been observed with insulin containing cells in fixed sections of pancreas from human, porcine, dog, rabbit, bovine, sheep, rat, guinea pig and cat. -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Human insulin.
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阳性对照
- IHC: Pancreas tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.05% Sodium azide
Constituents: PBS, BSA -
Concentration information loading... -
纯度
Ascites -
纯化说明
Ascites diluted in a PBS-based diluent. -
克隆
单克隆 -
克隆编号
K36aC10 -
同种型
IgG1 -
研究领域
相关产品
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Affibody® Molecule
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Compatible Secondaries
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Isotype control
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P | (5) |
1/25 - 1/50.
|
| 说明 |
|---|
|
IHC-P
1/25 - 1/50. |
靶标
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功能
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. -
疾病相关
Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].
Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. -
序列相似性
Belongs to the insulin family. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 3630 Human
- Omim: 176730 Human
- SwissProt: P01308 Human
- Unigene: 272259 Human
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别名
- IDDM antibody
- IDDM1 antibody
- IDDM2 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Insulin antibody [K36aC10] (ab6995)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human pancreas tissue labelling insulin with ab6995 at 1/25 dilution.
数据表及文件
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SDS download
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Datasheet download
文献 (87)
ab6995 被引用在 87 文献中.
- Li F et al. VGLL4 and MENIN function as TEAD1 corepressors to block pancreatic β cell proliferation. Cell Rep 42:111904 (2023). PubMed: 36662616
- Sridhar A et al. PYY (3-36) protects against high fat feeding induced changes of pancreatic islet and intestinal hormone content and morphometry. Biochim Biophys Acta Gen Subj 1867:130359 (2023). PubMed: 37001706
- Tanday N et al. Sex-based impact of pancreatic islet stressors in GluCreERT2/Rosa26-eYFP mice. J Endocrinol 259:N/A (2023). PubMed: 37650517
- Rout S et al. In Vitro Human Fetal Pancreatic Islets to Redefine Pancreatic Research. Cureus 15:e43244 (2023). PubMed: 37692623
- Mubarak HA et al. The ameliorating effects of mesenchymal stem cells compared to α-tocopherol on apoptosis and autophagy in streptozotocin-induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero-insular axis. J Cell Biochem 124:1705-1719 (2023). PubMed: 37796145