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AB69696

Anti-INPP5E抗体

Anti-INPP5E antibody

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(2 Publications)

Mouse Polyclonal INPP5E antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Phosphatidylinositol polyphosphate 5-phosphatase type IV.

查看别名

Phosphatidylinositol polyphosphate 5-phosphatase type IV, 72 kDa inositol polyphosphate 5-phosphatase, Inositol polyphosphate-5-phosphatase E, INPP5E

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human Phosphatidylinositol polyphosphate 5-phosphatase type IV.

Q9NRR6

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替代产品

Primary Antibodies

AB191520

Anti-INPP5E antibody

Western blot - Anti-INPP5E antibody (AB191520)

  • 0
  • 0
Primary Antibodies

AB236108

Anti-INPP5E antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INPP5E antibody (AB236108)

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搭配使用产品

Primary Antibodies

AB136648

Anti-ARL13B antibody [N295B/66]

BOND RX™ Validated|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARL13B antibody [N295B/66] (AB136648)

  • 5
  • 2
Primary Antibodies

AB52866

Anti-alpha Tubulin antibody [EP1332Y] - Loading Control

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-alpha Tubulin antibody [EP1332Y] - Loading Control (AB52866)

  • 5
  • 31
Proteins & Peptides

AB163384

Recombinant Human INPP5E protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human INPP5E protein (GST tag N-Terminus) (AB163384)

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Primary Antibodies

AB131272

Anti-ACTL6A antibody [EPR7443]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACTL6A antibody [EPR7443] (AB131272)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
存储溶液
pH: 7.4 Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

INPP5E also known as type I inositol polyphosphate-5-phosphatase plays a significant role as an enzyme regulating phosphoinositide signaling. This protein has a molecular mass of approximately 72 kDa. INPP5E cleaves the 5-phosphate from phosphoinositides affecting cellular processes. It is widely expressed in various tissues with notable presence in the brain and testis indicating its importance in these tissue types.
Biological function summary

INPP5E is involved in maintaining phosphoinositide balance within cells which regulates cellular signaling pathways. It is essential for the function of primary cilia by controlling ciliary membrane composition. This protein often interacts with components of the ciliary transition zone forming part of the complex that regulates trafficking proteins and movement.

Pathways

INPP5E engages in the phosphoinositide signaling pathway and the ciliary signaling pathway. It influences the activity of proteins such as phosphatidylinositol and adenylyl cyclase playing a role in signaling cascades that affect cell metabolism and spatial orientation. Disruption in its function can alter these signaling pathways demonstrating its importance in cellular communication and function.

Studies link INPP5E to Joubert syndrome and Meckel syndrome conditions affecting ciliary function. These ciliopathies are marked by abnormal brain development and a range of other symptoms. INPP5E interacts with proteins like ARL13B and CEP290 which are also associated with these disorders highlighting its integral role in maintaining healthy ciliary architecture and function.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity) (PubMed : 10764818). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed : 10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity).
See full target information Phosphatidylinositol polyphosphate 5-phosphatase type IV
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

PloS one 15:e0235803 PubMed33031374

2020

Toll like Receptor signalling by Prevotella histicola activates alternative NF-κB signalling in Cystic Fibrosis bronchial epithelial cells compared to P. aeruginosa.

Applications

Unspecified application

Species

Unspecified reactive species

Anne Bertelsen,Stuart J Elborn,Bettina C Schock

Cell reports 29:4010-4023.e5 PubMed31851930

2019

Induction of an Alternative mRNA 5' Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Huy-Dung Hoang,Tyson E Graber,Jian-Jun Jia,Nasana Vaidya,Victoria H Gilchrist,Xiao Xiang,Wencheng Li,Kyle N Cowan,Christos G Gkogkas,Maritza Jaramillo,Seyed Mehdi Jafarnejad,Tommy Alain
View all publications
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