重组Anti-Inhibin beta A抗体[EPR2785(2)] (ab128958)
![OI-RD Scanning - Anti-Inhibin beta A antibody [EPR2785(2)] (ab128958)](https://www.abcam.cn/ps/products/128/ab128958/Images/ab128958-142858-anti-inhibin-beta-a-antibody-epr27852.jpg "OI-RD Scanning - Anti-Inhibin beta A antibody [EPR2785(2)] (ab128958)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR2785(2)] to Inhibin beta A
- Suitable for: WB
- Reacts with: Mouse, Human
Related conjugates and formulations
概述
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产品名称
Anti-Inhibin beta A抗体[EPR2785(2)]
参阅全部 Inhibin beta A 一抗 -
描述
兔单克隆抗体[EPR2785(2)] to Inhibin beta A -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF,IHC-P or IP -
种属反应性
与反应: Mouse, Human
预测可用于: Rat
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免疫原
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阳性对照
- Recombinant Human Inhibin beta A protein
Fetal brain, fetal liver and mouse brain lysates
- Recombinant Human Inhibin beta A protein
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
解离常数（KD）
KD = 1.93 x 10 -10 M Learn more about KD -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR2785(2) -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab128958于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000 - 1/10000. Detects a band of approximately 43 kDa (predicted molecular weight: 47 kDa).
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| 说明 |
|---|
|
WB
1/1000 - 1/10000. Detects a band of approximately 43 kDa (predicted molecular weight: 47 kDa). |
应用说明
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
靶标
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功能
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. -
序列相似性
Belongs to the TGF-beta family. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 3624 Human
- Entrez Gene: 16323 Mouse
- Entrez Gene: 29200 Rat
- Omim: 147290 Human
- SwissProt: P08476 Human
- SwissProt: Q04998 Mouse
- SwissProt: P18331 Rat
- Unigene: 583348 Human
see all -
别名
- Activin beta-A chain antibody
- EDF antibody
- Erythroid differentiation factor antibody
see all
图片
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OI-RD Scanning - Anti-Inhibin beta A antibody [EPR2785(2)] (ab128958)
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![Western blot - Anti-Inhibin beta A antibody [EPR2785(2)] (ab128958)](https://www.abcam.cn/ps/products/128/ab128958/Images/ab128958-142860-anti-inhibin-beta-a-antibody-epr27852-western-blot.jpg)
Western blot - Anti-Inhibin beta A antibody [EPR2785(2)] (ab128958)Anti-Inhibin beta A antibody [EPR2785(2)] (ab128958) at 1/1000 dilution + Human Inhibin beta A recombinant protein at 0.001 µg
Secondary
HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 47 kDa -
![Western blot - Anti-Inhibin beta A antibody [EPR2785(2)] (ab128958)](https://www.abcam.cn/ps/products/128/ab128958/Images/ab128958-142859-anti-inhibin-beta-a-antibody-epr27852-western-blot.jpg)
Western blot - Anti-Inhibin beta A antibody [EPR2785(2)] (ab128958)All lanes : Anti-Inhibin beta A antibody [EPR2785(2)] (ab128958) at 1/1000 dilution
Lane 1 : Fetal brain lysate
Lane 2 : Fetal liver lysate
Lane 3 : Mouse brain lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 47 kDa
Observed band size: 43 kDa why is the actual band size different from the predicted? -
![Anti-Inhibin beta A antibody [EPR2785(2)] (ab128958)](https://www.abcam.cn/ps/products/128/ab128958/Images/ab128958-4-benefits-of-recombinant-antibodies.png)
Anti-Inhibin beta A antibody [EPR2785(2)] (ab128958)
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab128958 被引用在 5 文献中.
- Zhang W et al. GDF-15 in tumor-derived exosomes promotes muscle atrophy via Bcl-2/caspase-3 pathway. Cell Death Discov 8:162 (2022). PubMed: 35379793
- Reader KL et al. Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth. Cancers (Basel) 15:N/A (2022). PubMed: 36612143
- Xian S et al. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial-mesenchymal transition in the valvular damage due to rheumatic heart disease. Mol Med Rep 23:N/A (2021). PubMed: 33179113
- Guo J & Liu Y INHBA promotes the proliferation, migration and invasion of colon cancer cells through the upregulation of VCAN. J Int Med Res 49:3000605211014998 (2021). PubMed: 34130530
- Wu Y et al. Autocrine transforming growth factor-ß/activin A-Smad signaling induces hepatic progenitor cells undergoing partial epithelial-mesenchymal transition states. Biochimie 148:87-98 (2018). PubMed: 29544731