Anti-ING4抗体(ab113425)
Key features and details
- Rabbit polyclonal to ING4
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-ING4抗体
参阅全部 ING4 一抗 -
描述
兔多克隆抗体to ING4 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat
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免疫原
Recombinant fragment, corresponding to internal sequence amino acids 33-183 of Human ING4, isoform 3 (BC007781).
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阳性对照
- Human fetal liver, fetal kidney and Mouse kidney lysates; Human fetal brain tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Reconstitute in 200ul sterile H2O. -
存放说明
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituent: 1% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
ab113425 is purified by a protein affinity column. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab113425于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/1000. Detects a band of approximately 25 kDa (predicted molecular weight: 26 kDa).
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| IHC-P |
1/100 - 1/500.
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| 说明 |
|---|
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WB
1/500 - 1/1000. Detects a band of approximately 25 kDa (predicted molecular weight: 26 kDa). |
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IHC-P
1/100 - 1/500. |
靶标
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功能
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). -
序列相似性
Belongs to the ING family.
Contains 1 PHD-type zinc finger. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 51147 Human
- Entrez Gene: 28019 Mouse
- Entrez Gene: 297597 Rat
- Omim: 608524 Human
- SwissProt: Q9UNL4 Human
- SwissProt: Q8C0D7 Mouse
- Unigene: 524210 Human
- Unigene: 262547 Mouse
see all -
别名
- Brain my036 protein antibody
- Candidate tumor suppressor p33 ING 1 homolog antibody
- Candidate tumor suppressor p33 ING1 homolog antibody
see all
图片
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Western blot - Anti-ING4 antibody (ab113425)All lanes : Anti-ING4 antibody (ab113425) at 1/500 dilution
Lane 1 : Human fetal liver lysate
Lane 2 : Human fetal kidney lysate
Lane 3 : Mouse kidney lysate
Predicted band size: 26 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ING4 antibody (ab113425)ab113425 at 1/100 dilution staining ING4 in Formalin-fixed, Paraffin-embedded Human fetal brain tissue by Immunohistochemistry. Note nuclear staining.
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab113425 被引用在 4 文献中.
- Ma T et al. Lentiviral vector with a radiation-inducible promoter, carrying the ING4 gene, mediates radiosensitization controlled by radiotherapy in cervical cancer cells. Oncol Lett 21:67 (2021). PubMed: 33365078
- Tang X et al. miR-650 promotes non-small cell lung cancer cell proliferation and invasion by targeting ING4 through Wnt-1/ß-catenin pathway. Oncol Lett 18:4621-4628 (2019). PubMed: 31611970
- Sun J et al. Inhibitor of growth 4 inhibits cell proliferation, migration, and induces apoptosis of renal cell carcinoma cells. J Cell Biochem N/A:N/A (2018). PubMed: 30390334
- Shao B & Liu E Expression of ING4 is negatively correlated with cellular proliferation and microvessel density in human glioma. Oncol Lett 14:3663-3668 (2017). PubMed: 28927128