Anti-Influenza Virus NS1A Binding Protein 抗体

靶点信息

Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed : 16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed : 25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed : 9696811). May play a role in mRNA nuclear export (PubMed : 30538201).. (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein (PubMed : 23825951, PubMed : 9696811). The BTB and Kelch domains are required for splicing activity (PubMed : 30538201). Promotes export of viral M mRNA and RNP via its interaction with mRNA export factor ALYREF (PubMed : 30538201).