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AB5416

Anti-Influenza A Virus M2 Protein 抗体 [14C2]

Anti-Influenza A Virus M2 Protein antibody [14C2]

5

(2 Reviews)

|

(72 Publications)

Mouse Monoclonal M2 antibody. Suitable for ICC and reacts with Influenza A samples. Cited in 72 publications.

查看别名

Influenza A virus matrix protein M2, Matrix protein 2, Membrane ion channel M2, Membrane protein M2, Proton channel protein M2

1 Images
Immunocytochemistry - Anti-Influenza A Virus M2 Protein antibody [14C2] (AB5416)
  • ICC

Unknown

Immunocytochemistry - Anti-Influenza A Virus M2 Protein antibody [14C2] (AB5416)

Immunofluorescence staining of infected dog MDCK cells using ab5416.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

14C2

亚型

IgG1

轻链类型

kappa

不含载体蛋白

No

反应种属

Influenza A

应用

ICC

applications

表位

Detects the N-terminal of the Influenza A Virus M2 Protein.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Influenza A": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "1 µg/mL", "ICC-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
存储溶液
Preservative: 0.05% Sodium azide Constituents: 99% PBS, 0.1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Influenza A Virus M2 Protein also known as M2 ion channel or matrix protein 2 plays an essential role in the viral life cycle. This protein has a mass of approximately 97 amino acids and is expressed on the envelope of the Influenza A virus. It functions as a proton-selective channel facilitating the acidification of the viral interior after the virus enters the host cell. This acidification process is important for the uncoating of the viral genome allowing subsequent replication of the virus in host cells.
Biological function summary

The M2 protein from Influenza A virus participates in virus assembly budding and release. The protein operates as a tetramer creating a channel across the viral membrane. This channel is essential for the correct function and structure of the virus playing an important role in membrane fusion and release of the viral particles. It often works in conjunction with another matrix protein M1 which assists in stabilizing the integrity of the viral structure.

Pathways

The M2 Influenza protein is integral to the viral replication and assembly pathway. It aligns with the function of the viral ribonucleoprotein complex and is significant in the viral entry and exit pathways. Additionally the connection to the M1 matrix protein highlights its coordinated role in facilitating the assembly and release of new virions from the infected cells emphasizing its necessity in productive viral replication.

The Influenza A virus M2 protein is directly related to the pathogenesis of seasonal influenza. Antiviral drugs like amantadine and rimantadine target this ion channel to disrupt viral replication. Resistance mutations in the M2 protein can influence the efficacy of these drugs impacting treatment outcomes. There is also a link with immune system responses where M2 interactions with other viral proteins can modulate host immune evasion mechanisms.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

See full target information Influenza A Virus M2 Protein
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文献 (72)

Recent publications for all applications. Explore the full list and refine your search

JACC. Basic to translational science 7:1214-1228 PubMed36644282

2022

Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah Evans,Xiucui Ma,Xiqiang Wang,Yana Chen,Chen Zhao,Carla J Weinheimer,Attila Kovacs,Brian Finck,Abhinav Diwan,Douglas L Mann

Biophysical journal 120:5478-5490 PubMed34808098

2021

Influenza A M2 recruits M1 to the plasma membrane: A fluorescence fluctuation microscopy study.

Applications

Unspecified application

Species

Unspecified reactive species

Annett Petrich,Valentin Dunsing,Sara Bobone,Salvatore Chiantia

Cell reports 37:109899 PubMed34706226

2021

Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel Ulferts,Elena Marcassa,Lewis Timimi,Liam Changwoo Lee,Andrew Daley,Beatriz Montaner,Suzanne Dawn Turner,Oliver Florey,John Kenneth Baillie,Rupert Beale

mBio 12:e0148421 PubMed34517760

2021

MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Fernando Villalón-Letelier,Andrew G Brooks,Sarah L Londrigan,Patrick C Reading

Viruses 13: PubMed34578289

2021

Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses.

Applications

Unspecified application

Species

Unspecified reactive species

Nutan Mytle,Sonja Leyrer,Jon R Inglefield,Andrea M Harris,Thomas E Hickey,Jacob Minang,Hang Lu,Zhidong Ma,Hanné Andersen,Nathan D Grubaugh,Tina Guina,Mario H Skiadopoulos,Michael J Lacy

Molecular cell 81:2031-2040.e8 PubMed33909989

2021

Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.

Applications

Unspecified application

Species

Unspecified reactive species

Joanne Durgan,Alf H Lystad,Katherine Sloan,Sven R Carlsson,Michael I Wilson,Elena Marcassa,Rachel Ulferts,Judith Webster,Andrea F Lopez-Clavijo,Michael J Wakelam,Rupert Beale,Anne Simonsen,David Oxley,Oliver Florey

Cellular microbiology 23:e13322 PubMed33629465

2021

NS1-mediated upregulation of ZDHHC22 acyltransferase in influenza a virus infected cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mohamed Rasheed Gadalla,Eliot Morrison,Marina V Serebryakova,Xueijiao Han,Thorsten Wolff,Christian Freund,Larisa Kordyukova,Michael Veit

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:2004555 PubMed33977069

2021

Trojan Horse Delivery of 4,4'-Dimethoxychalcone for Parkinsonian Neuroprotection.

Applications

Unspecified application

Species

Unspecified reactive species

Wenlong Zhang,Huaqing Chen,Liuyan Ding,Junwei Gong,Mengran Zhang,Wenyuan Guo,Pingyi Xu,Shiying Li,Yunlong Zhang

Vaccines 9: PubMed33669126

2021

-Based Cell-Free Protein Synthesis for Iterative Design of Tandem-Core Virus-Like Particles.

Applications

Unspecified application

Species

Unspecified reactive species

Noelle Colant,Beatrice Melinek,Stefanie Frank,William Rosenberg,Daniel G Bracewell

PLoS pathogens 17:e1009340 PubMed33596274

2021

Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy.

Applications

Unspecified application

Species

Unspecified reactive species

Irene Pila-Castellanos,Diana Molino,Joe McKellar,Laetitia Lines,Juliane Da Graca,Marine Tauziet,Laurent Chanteloup,Ivan Mikaelian,Laurène Meyniel-Schicklin,Patrice Codogno,Jacky Vonderscher,Cédric Delevoye,Olivier Moncorgé,Eric Meldrum,Caroline Goujon,Etienne Morel,Benoit de Chassey
View all publications
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