Anti-Influenza A Virus 抗体
Anti-Influenza A Virus antibody
3
(1 Review)
|
(23 Publications)
- Over 20 publications
- Trusted since 2005
- IHC-P
PubMed
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Influenza A Virus antibody (AB20841)
ab20841 staining Influenza A Virus in reconstructed 1918 H1N1 influenza infected Mouse lung tissue sections by Immunohistochemistry. Tissue was fixed with 10% neutral-buffered formalin and embedded in paraffin. Slides were deparaffinized, rehydrated in water, steam antigen retrieved in pH 6 citrate buffer, and blocked with 3% H2O2. Samples were incubated with primary antibody (1/500) for 1 hour at room temperature. Top - EUK-207 treated mouse, 8 days postinfection, Bottom uninfected mouse control. Brown staining indicates positive staining in cell's cytoplasm and/or nucleus. Cellular debris is also frequently positive.
Image from Kash JC et al., Free Radic Biol Med. 2013;67C:235-247. Fig 3.; doi: 10.1016/j.freeradbiomed.2013.10.014 with permission from Elsevier.
反应性数据
产品详情
Anti-Influenza A Virus antibody (ab20841) is a goat polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Influenza A samples.
Trusted by the scientific community
Anti-Influenza A Virus (ab20841) was first used in a scientific publication in 2005 and has been cited over 20 times in peer-reviewed journals.
性能和储存信息
形式
纯化工艺
纯化说明
存储溶液
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The Influenza A virus interferes with normal cellular functions. As it enters and replicates within host cells it triggers immune responses that seek to neutralize the virus a process often targeted by flu antibodies and anti-influenza therapies like arbidol 20 mg. The virus can hijack the host cell machinery to produce viral proteins and RNA forming complexes with cellular components to facilitate new virion assembly. This interaction often leads to the production of cytokines and can induce inflammation an important feature of infection by Influenza Type A.
Pathways
The Influenza A virus interacts with cellular pathways involved in endocytosis and RNA replication. It exploits the host cell's clathrin-mediated endocytosis for entry making use of the cellular machinery. In the context of RNA replication the virus's RNA-dependent RNA polymerase complex plays a critical role working alongside host cell proteins to synthesize viral RNA. The virus has well-documented interactions with proteins such as M1 matrix protein and NS1 non-structural protein which modulate both viral replication and interference with host immune responses.
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文献 (23)
Recent publications for all applications. Explore the full list and refine your search
Journal of virology 96:e0134122 PubMed36326278
2022
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Journal of virology 95:e0013021 PubMed33893170
2021
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Journal of virology 95: PubMed33762409
2021
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Journal of virology 95: PubMed33504608
2021
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The EMBO journal 39:e103476 PubMed32985719
2020
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Journal of virology 94: PubMed32321802
2020
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Viruses 10: PubMed29783694
2018
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Viruses 9: PubMed29258238
2017
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Nature immunology 17:626-35 PubMed27111143
2016
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The Journal of clinical investigation 126:1566-80 PubMed26999599
2016
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