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AB20841

Anti-Influenza A Virus 抗体

Anti-Influenza A Virus antibody

3

(1 Review)

|

(23 Publications)

Anti-Influenza A Virus antibody (ab20841) is a goat polyclonal antibody detecting Influenza A Virus in IHC-P, ICC/IF. Suitable for Influenza A.

- Over 20 publications
- Trusted since 2005
1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Influenza A Virus antibody (AB20841)
  • IHC-P

PubMed

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Influenza A Virus antibody (AB20841)

ab20841 staining Influenza A Virus in reconstructed 1918 H1N1 influenza infected Mouse lung tissue sections by Immunohistochemistry. Tissue was fixed with 10% neutral-buffered formalin and embedded in paraffin. Slides were deparaffinized, rehydrated in water, steam antigen retrieved in pH 6 citrate buffer, and blocked with 3% H2O2. Samples were incubated with primary antibody (1/500) for 1 hour at room temperature. Top - EUK-207 treated mouse, 8 days postinfection, Bottom uninfected mouse control. Brown staining indicates positive staining in cell's cytoplasm and/or nucleus. Cellular debris is also frequently positive.

Image from Kash JC et al., Free Radic Biol Med. 2013;67C:235-247. Fig 3.; doi: 10.1016/j.freeradbiomed.2013.10.014 with permission from Elsevier.

关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Influenza A

应用

ICC/IF, IHC-P

applications

反应性数据

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产品详情

What is this antibody validated in?
Anti-Influenza A Virus antibody (ab20841) is a goat polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Influenza A samples.

Trusted by the scientific community
Anti-Influenza A Virus (ab20841) was first used in a scientific publication in 2005 and has been cited over 20 times in peer-reviewed journals.

性能和储存信息

形式
Liquid
纯化工艺
Ion exchange chromatography
纯化说明
>95% pure. Sodium sulfate precipitation and ion-exchange chromatography.
存储溶液
Preservative: 0.1% Sodium azide Constituents: 0.0268% PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Influenza A virus also known as "flu A" is an important pathogen with a complex life cycle. Mechanically it consists of several proteins including hemagglutinin (HA) and neuraminidase (NA) which facilitate the virus's entry and release from host cells. The mass of the Influenza A virus is not a single value as it is a non-uniform entity composed of different proteins and RNA segments. This virus is mainly expressed in the epithelial cells of the respiratory tract in humans and other organisms. Through antigenic drift and shift the virus changes over time which makes it a significant challenge for public health.
Biological function summary

The Influenza A virus interferes with normal cellular functions. As it enters and replicates within host cells it triggers immune responses that seek to neutralize the virus a process often targeted by flu antibodies and anti-influenza therapies like arbidol 20 mg. The virus can hijack the host cell machinery to produce viral proteins and RNA forming complexes with cellular components to facilitate new virion assembly. This interaction often leads to the production of cytokines and can induce inflammation an important feature of infection by Influenza Type A.

Pathways

The Influenza A virus interacts with cellular pathways involved in endocytosis and RNA replication. It exploits the host cell's clathrin-mediated endocytosis for entry making use of the cellular machinery. In the context of RNA replication the virus's RNA-dependent RNA polymerase complex plays a critical role working alongside host cell proteins to synthesize viral RNA. The virus has well-documented interactions with proteins such as M1 matrix protein and NS1 non-structural protein which modulate both viral replication and interference with host immune responses.

Influenza A is a major cause of seasonal flu outbreaks and pandemics. It can lead to acute respiratory illness and is linked to life-threatening conditions like pneumonia. The virus often coexists in the respiratory system with other pathogens complicating the disease course. Proteins such as neuraminidase are important in its role in spreading the infection and represent targets for anti-flu therapies. The connection between Influenza A virus cytokine responses and severe respiratory conditions makes understanding its interaction with host proteins essential for developing effective treatments.

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

文献 (23)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 96:e0134122 PubMed36326278

2022

Respiratory Syncytial Virus Protects Bystander Cells against Influenza A Virus Infection by Triggering Secretion of Type I and Type III Interferons.

Applications

Unspecified application

Species

Unspecified reactive species

Maciej Czerkies,Marek Kochańczyk,Zbigniew Korwek,Wiktor Prus,Tomasz Lipniacki

Journal of virology 95:e0013021 PubMed33893170

2021

Human Nasal and Lung Tissues Infected with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory Tract.

Applications

Unspecified application

Species

Unspecified reactive species

Or Alfi,Arkadi Yakirevitch,Ori Wald,Ori Wandel,Uzi Izhar,Esther Oiknine-Djian,Yuval Nevo,Sharona Elgavish,Elad Dagan,Ory Madgar,Gilad Feinmesser,Eli Pikarsky,Michal Bronstein,Olesya Vorontsov,Wayne Jonas,John Ives,Joan Walter,Zichria Zakay-Rones,Menachem Oberbaum,Amos Panet,Dana G Wolf

Journal of virology 95: PubMed33762409

2021

Thiopurines activate an antiviral unfolded protein response that blocks influenza A virus glycoprotein accumulation.

Applications

Unspecified application

Species

Unspecified reactive species

Patrick D Slaine,Mariel Kleer,Brett A Duguay,Eric S Pringle,Eileigh Kadijk,Shan Ying,Aruna Balgi,Michel Roberge,Craig McCormick,Denys A Khaperskyy

Journal of virology 95: PubMed33504608

2021

The influenza A virus host shutoff factor PA-X is rapidly turned over in a strain-specific manner.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel Emily Levene,Shailab D Shrestha,Marta Maria Gaglia

The EMBO journal 39:e103476 PubMed32985719

2020

Multilineage murine stem cells generate complex organoids to model distal lung development and disease.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Ivonne Vazquez-Armendariz,Monika Heiner,Elie El Agha,Isabelle Salwig,Andreas Hoek,Marie Christin Hessler,Irina Shalashova,Amit Shrestha,Gianni Carraro,Jan Philip Mengel,Andreas Günther,Rory Edward Morty,István Vadász,Martin Schwemmle,Wolfgang Kummer,Torsten Hain,Alexander Goesmann,Saverio Bellusci,Werner Seeger,Thomas Braun,Susanne Herold

Journal of virology 94: PubMed32321802

2020

Defective Influenza A Virus RNA Products Mediate MAVS-Dependent Upregulation of Human Leukocyte Antigen Class I Proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Mir Munir A Rahim,Brendon D Parsons,Emma L Price,Patrick D Slaine,Becca L Chilvers,Gregory S Seaton,Andrew Wight,Daniel Medina-Luna,Sayanti Dey,Shannen L Grandy,Lauryn E Anderson,Natalia Zamorano Cuervo,Nathalie Grandvaux,Marta M Gaglia,Alyson A Kelvin,Denys A Khaperskyy,Craig McCormick,Andrew P Makrigiannis

Viruses 10: PubMed29783694

2018

Adaptive Mutations in Influenza A/California/07/2009 Enhance Polymerase Activity and Infectious Virion Production.

Applications

Unspecified application

Species

Unspecified reactive species

Patrick D Slaine,Cara MacRae,Mariel Kleer,Emily Lamoureux,Sarah McAlpine,Michelle Warhuus,André M Comeau,Craig McCormick,Todd Hatchette,Denys A Khaperskyy

Viruses 9: PubMed29258238

2017

Stress Granule-Inducing Eukaryotic Translation Initiation Factor 4A Inhibitors Block Influenza A Virus Replication.

Applications

Unspecified application

Species

Unspecified reactive species

Patrick D Slaine,Mariel Kleer,Nathan K Smith,Denys A Khaperskyy,Craig McCormick

Nature immunology 17:626-35 PubMed27111143

2016

Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathan S Silver,Jennifer Kearley,Alan M Copenhaver,Caroline Sanden,Michiko Mori,Li Yu,Gretchen Harms Pritchard,Aaron A Berlin,Christopher A Hunter,Russell Bowler,Jonas S Erjefalt,Roland Kolbeck,Alison A Humbles

The Journal of clinical investigation 126:1566-80 PubMed26999599

2016

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.

Applications

Unspecified application

Species

Unspecified reactive species

Christin Peteranderl,Luisa Morales-Nebreda,Balachandar Selvakumar,Emilia Lecuona,István Vadász,Rory E Morty,Carole Schmoldt,Julia Bespalowa,Thorsten Wolff,Stephan Pleschka,Konstantin Mayer,Stefan Gattenloehner,Ludger Fink,Juergen Lohmeyer,Werner Seeger,Jacob I Sznajder,Gökhan M Mutlu,G R Scott Budinger,Susanne Herold
View all publications

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