Anti-IMPACT抗体(ab72444)
Key features and details
- Mouse polyclonal to IMPACT
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-IMPACT抗体
参阅全部 IMPACT 一抗 -
描述
小鼠多克隆抗体to IMPACT -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat, Human -
免疫原
Full length native protein (purified), corresponding to amino acids 1-320 of Human IMPACT
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.40
Constituent: 100% PBS -
Concentration information loading... -
纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab72444于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use at an assay dependent dilution. Predicted molecular weight: 36 kDa.
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| 说明 |
|---|
|
WB
Use at an assay dependent dilution. Predicted molecular weight: 36 kDa. |
靶标
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功能
Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. -
组织特异性
Widely expressed. Expressed at high level in brain. -
序列相似性
Belongs to the IMPACT family.
Contains 1 RWD domain. - Information by UniProt
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数据库链接
- Entrez Gene: 55364 Human
- Entrez Gene: 497198 Rat
- SwissProt: Q9P2X3 Human
- SwissProt: Q5GFD9 Rat
- Unigene: 515317 Human
- Unigene: 190651 Rat
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别名
- IMPACT antibody
- Impact homolog (mouse) antibody
- Impact homolog antibody
see all
图片
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Western blot - Anti-IMPACT antibody (ab72444)Anti-IMPACT antibody (ab72444) + Rat brain
Secondary
HRP-conjugated goat anti-mouse IgG (H&L)
Predicted band size: 36 kDa -
Western blot - Anti-IMPACT antibody (ab72444)All lanes : Anti-IMPACT antibody (ab72444)
Lane 1 : IMPACT transfected lysate (human 293T cell line)
Lane 2 : Non-transfected lysate
Predicted band size: 36 kDa
数据表及文件
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Datasheet download
文献 (2)
ab72444 被引用在 2 文献中.
- Tajima Y et al. NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons. Cell Rep 42:112050 (2023). PubMed: 36716149
- Habibi D et al. High expression of IMPACT protein promotes resistance to indoleamine 2,3-dioxygenase-induced cell death. J Cell Physiol 225:196-205 (2010). WB ; Human . PubMed: 20648630
