Anti-IL1 Receptor I/IL-1R-1抗体[REG21] (ab8154)
Key features and details
- Rat monoclonal [REG21] to IL1 Receptor I/IL-1R-1
- Suitable for: Inhibition Assay, IP, Purification, WB
- Reacts with: Mouse
- Isotype: IgG1
概述
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产品名称
Anti-IL1 Receptor I/IL-1R-1抗体[REG21]
参阅全部 IL1 Receptor I/IL-1R-1 一抗 -
描述
大鼠单克隆抗体[REG21] to IL1 Receptor I/IL-1R-1 -
宿主
Rat -
特异性
Binds to soluble mouse interleukin-1 receptor type I. Interleukin-1 signal is transduced through the type I receptor. -
经测试应用
适用于: Inhibition Assay, IP, Purification, WBmore details -
种属反应性
与反应: Mouse -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide -
Concentration information loading... -
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
REG21 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Inhibition Assay |
Use at an assay dependent concentration.
|
|
| IP |
Use at an assay dependent concentration.
|
|
| Purification |
Use at an assay dependent concentration.
|
|
| WB |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
Inhibition Assay
Use at an assay dependent concentration. |
|
IP
Use at an assay dependent concentration. |
|
Purification
Use at an assay dependent concentration. |
|
WB
Use at an assay dependent concentration. |
靶标
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功能
Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2. -
序列相似性
Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 16177 Mouse
- SwissProt: P13504 Mouse
- Unigene: 896 Mouse
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别名
- Antigen CD121a antibody
- CD121 antigen-like family member A antibody
- CD121a antibody
see all
数据表及文件
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Datasheet download
文献 (1)
ab8154 被引用在 1 文献中.
- Pasi S et al. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response. J Biol Chem 291:12358-69 (2016). PubMed: 27022030
