AB180894

Anti-IL-36R抗体

Name: IL-36R抗体 (ab180894)| Abcam中文官网
Brand: Abcam Limited
SKU: AB180894
Price: 6230 CNY
Availability: InStock

Anti-IL-36R antibody

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(7 Publications)

Rabbit Polyclonal IL-36R antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human IL1RL2.

查看别名

IL1RRP2, IL1RL2, Interleukin-1 receptor-like 2, IL-36 receptor, Interleukin-1 receptor-related protein 2, IL-36R, IL-1Rrp2, IL1R-rp2

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-36R antibody (AB180894)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-36R antibody (AB180894)

Immunohistochemical analysis of paraffin-embedded Human small intestine tissue labeling IL1RL2 with ab180894 at 5 μg/ml.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-36R antibody (AB180894)

Immunohistochemical analysis of paraffin-embedded Human small intestine tissue labeling IL1RL2 with ab180894 at 20 μg/ml.

Supplier Data

Western blot - Anti-IL-36R antibody (AB180894)

Lane 1:

Western blot - Anti-IL-36R antibody (ab180894) at 1 µg/mL

Lane 2:

Western blot - Anti-IL-36R antibody (ab180894) at 2 µg/mL

All lanes:

Human small intestine lysate at 15 µg

Predicted band size: 65 kDa

Observed band size: 55 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Synthetic Peptide within Human IL1RL2. The exact immunogen used to generate this antibody is proprietary information.

Q9HB29

特异性

ab180894 will detect all three isoforms of IL1RL2. ab180894 is predicted to not cross-react with IL1 Receptor I or ST2.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

See full target information IL1RL2

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:7662 PubMed39266531

2024

IL36G-producing neutrophil-like monocytes promote cachexia in cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshihiro Hayashi,Yasushige Kamimura-Aoyagi,Sayuri Nishikawa,Rena Noka,Rika Iwata,Asami Iwabuchi,Yushin Watanabe,Natsumi Matsunuma,Kanako Yuki,Hiroki Kobayashi,Yuka Harada,Hironori Harada

British journal of pharmacology 179:4378-4399 PubMed35481896

2022

Modulation of interleukin-36 based inflammatory feedback loop through the hepatocyte-derived IL-36R-P2X7R axis improves steatosis in alcoholic steatohepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Shang,Hong-Xu Yang,Xia Li,Yu Zhang,Nan Chen,Xue-Li Jiang,Zhi-Hong Zhang,Rong-Mei Zuo,Hui Wang,Xiao-Qi Lan,Jie Ren,Yan-Ling Wu,Zhen-Yu Cui,Ji-Xing Nan,Li-Hua Lian

Investigative ophthalmology & visual science 62:10 PubMed33970198

2021

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis.

Applications

Unspecified application

Species

Unspecified reactive species

Chenyang Dai,Rao Me,Nan Gao,Guanyu Su,Xinyi Wu,Fu-Shin X Yu

Technology in cancer research & treatment 20:1533033821995282 PubMed33602046

2021

The Potential Role of IL1RAP on Tumor Microenvironment-Related Inflammatory Factors in Stomach Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Lv,Qinghua Xia,Anshu Li,Zhiyong Wang

International journal of molecular sciences 22: PubMed33396613

2020

Role of IL-36 Cytokines in the Regulation of Angiogenesis Potential of Trophoblast Cells.

Applications

Unspecified application

Species

Unspecified reactive species

José M Murrieta-Coxca,Ruby N Gutiérrez-Samudio,Heba M El-Shorafa,Tanja Groten,Sandra Rodríguez-Martínez,Mario E Cancino-Diaz,Juan C Cancino-Diaz,Rodolfo R Favaro,Udo R Markert,Diana M Morales-Prieto

Glia 67:438-451 PubMed30578562

2018

Spinal IL-36γ/IL-36R participates in the maintenance of chronic inflammatory pain through astroglial JNK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Li,Shenbin Liu,Lingling Li,Xiaoli Ji,Min Wang,Junmei Zhou

Mucosal immunology 9:1193-204 PubMed26813344

2016

IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

S E Russell,R M Horan,A M Stefanska,A Carey,G Leon,M Aguilera,D Statovci,T Moran,P G Fallon,F Shanahan,E K Brint,S Melgar,S Hussey,P T Walsh

View all publications

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Abcam Product Promise

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For licensing inquiries, please contact partnerships@abcam.com

Anti-IL-36R抗体

Anti-IL-36R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-36R antibody (AB180894)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-36R antibody (AB180894)

Western blot - Anti-IL-36R antibody (AB180894)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性