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重组RabMAb

重组Anti-IL-23R抗体[EPR23806-141] - BSA and Azide free (Detector) (ab273681)

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Sandwich ELISA - Anti-IL-23R antibody [EPR23806-141] - BSA and Azide free (Detector) (ab273681)

    Key features and details

    • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
    • Rabbit monoclonal [EPR23806-141] to IL-23R - BSA and Azide free (Detector)
    • Suitable for: Sandwich ELISA
    • Reacts with: Human

    概述

    • 产品名称

      Anti-IL-23R抗体[EPR23806-141] - BSA and Azide free (Detector)
      参阅全部 IL-23R 一抗

    • 描述

      兔单克隆抗体[EPR23806-141] to IL-23R - BSA and Azide free (Detector)

    • 宿主

      Rabbit

    • 经测试应用

      适用于: Sandwich ELISAmore details

    • 种属反应性

      与反应: Human

    • 免疫原

      Recombinant fragment. This information is proprietary to Abcam and/or its suppliers.

    • 常规说明

      ab273681 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human IL-23R. The recommended pair for sandwich ELISA is:
          Capture: ab273680, Human IL-23R Capture Antibody (unconjugated)
          Detector: ab273681, Human IL-23R Detector Antibody (unconjugated)
      The reference range value is 31.25 - 2000 pg/ml.

      Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.

      This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

      Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

      The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

      This product is a recombinant monoclonal antibody, which offers several advantages including:

      • - High batch-to-batch consistency and reproducibility
      • - Improved sensitivity and specificity
      • - Long-term security of supply
      • - Animal-free production
      For more information see here.

      Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    性能

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab273681于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    Sandwich ELISA
    Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [EPR23806-45] to IL-23R - BSA and Azide free (Capture) (ab273680).
    说明
    Sandwich ELISA
    Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [EPR23806-45] to IL-23R - BSA and Azide free (Capture) (ab273680).

    靶标

    • 功能

      Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

    • 组织特异性

      Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.

    • 疾病相关

      Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
      Genetic variations in IL23R are a cause of susceptibility to psoriasis type 7 (PSORS7) [MIM:605606]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.

    • 序列相似性

      Belongs to the type I cytokine receptor family. Type 2 subfamily.
      Contains 2 fibronectin type-III domains.

    • 翻译后修饰

      Phosphorylated in response to IL23.

    • 细胞定位

      Cell membrane.
    • Information by UniProt

    • 数据库链接

      • 别名

        • IL 23R antibody
        • IL-23 receptor antibody
        • IL-23R antibody
        • IL23 Receptor antibody
        • Il23r antibody
        • IL23R_HUMAN antibody
        • Interleukin 23 receptor antibody
        • Interleukin-23 receptor antibody
        see all

      图片

      • Sandwich ELISA - Anti-IL-23R antibody [EPR23806-141] - BSA and Azide free (Detector) (ab273681)
        Sandwich ELISA - Anti-IL-23R antibody [EPR23806-141] - BSA and Azide free (Detector) (ab273681)
        Representative standard curve from corresponding SimpleStep ELISA® Kit (ab277716).

      实验方案

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      文献 (0)

      发表研究结果有使用 ab273681？请让我们知道，以便我们可以引用本数据表中的参考文章。

      ab273681 尚未被引用在任何文献中。

      客户评价及客户问答

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