Anti-IL-13 receptor alpha 1抗体(ab79277)
Key features and details
- Rabbit polyclonal to IL-13 receptor alpha 1
- Suitable for: WB, IHC-P, ICC/IF
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-IL-13 receptor alpha 1抗体
参阅全部 IL-13 receptor alpha 1 一抗 -
描述
兔多克隆抗体to IL-13 receptor alpha 1 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-P, ICC/IFmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide corresponding to Human IL-13 receptor alpha 1 (phospho Y405). (D-I-Y-E-K)
Database link: P78552 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.5% BSA
Without Mg2+ and Ca2+ -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab79277于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (1) |
1/500 - 1/1000. Predicted molecular weight: 47 kDa.
|
| IHC-P |
1/50 - 1/100.
|
|
| ICC/IF | (1) |
1/500 - 1/1000.
|
| 说明 |
|---|
|
WB
1/500 - 1/1000. Predicted molecular weight: 47 kDa. |
|
IHC-P
1/50 - 1/100. |
|
ICC/IF
1/500 - 1/1000. |
靶标
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功能
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. -
组织特异性
Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells. -
序列相似性
Belongs to the type I cytokine receptor family. Type 5 subfamily. -
结构域
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3597 Human
- Entrez Gene: 16164 Mouse
- Omim: 300119 Human
- SwissProt: P78552 Human
- SwissProt: O09030 Mouse
- Unigene: 496646 Human
- Unigene: 24208 Mouse
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别名
- bB128O4.2.1 (interleukin 13 receptor, alpha 1) antibody
- Cancer/testis antigen 19 antibody
- CD213a1 antibody
see all
图片
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Western blot - Anti-IL-13 receptor alpha 1 antibody (ab79277)All lanes : Anti-IL-13 receptor alpha 1 antibody (ab79277) at 1/500 dilution
Lane 1 : COLO cell extracts
Lane 2 : HT29 cell extracts
Lane 3 : A549 cell extracts
Lane 4 : 293 cell extracts
Lane 5 : COLO cell extracts with immunising peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size: 47 kDa
Observed band size: 50 kDa why is the actual band size different from the predicted? -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-13 receptor alpha 1 antibody (ab79277)ab79277 at 1/50 dilution staining IL-13 receptor alpha 1 in human breast carcinoma by Immunohistochemistry using paraffin-embedded tissue, in the absence or presence of the immunising peptide.
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Immunocytochemistry/ Immunofluorescence - Anti-IL-13 receptor alpha 1 antibody (ab79277)ab79277 at 1/500 dilution staining IL-13 receptor alpha 1 in NIH3T3 cells by Immunofluorescence, in the absence or presence of the immunising peptide.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (19)
ab79277 被引用在 19 文献中.
- Guo L et al. Drug suspending during wound healing effectively weakens immunosuppression-related complications by preserving CD8+ T cell function. Wound Repair Regen 31:489-499 (2023). PubMed: 37129099
- Shi J et al. Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer. Int J Mol Sci 23:N/A (2022). PubMed: 35409019
- Lu Z et al. IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis. FASEB J 36:e22334 (2022). PubMed: 35486004
- Van Broeckhoven J et al. Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury. J Neuroinflammation 19:102 (2022). PubMed: 35488301
- Zhu M et al. Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis. Int J Oral Sci 14:29 (2022). PubMed: 35718799