Anti-IL-1 alpha抗体(ab7632)
Key features and details
- Rabbit polyclonal to IL-1 alpha
- Suitable for: ELISA, IHC-Fr, Neutralising, ICC/IF, IHC-P, Flow Cyt, WB
- Reacts with: Mouse, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-IL-1 alpha抗体
参阅全部 IL-1 alpha 一抗 -
描述
兔多克隆抗体to IL-1 alpha -
宿主
Rabbit -
经测试应用
适用于: ELISA, IHC-Fr, Neutralising, ICC/IF, IHC-P, Flow Cyt, WBmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Non human primates -
免疫原
Recombinant full length protein corresponding to Human IL-1 alpha.
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阳性对照
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride -
Concentration information loading...
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纯度
IgG fraction -
纯化说明
whole rabbit serum purified by DEAE fractionation -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
应用
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
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Neutralising |
Use at an assay dependent concentration.
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ICC/IF | (2) |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration. PubMed: 22190968
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Flow Cyt | (1) |
Use at an assay dependent concentration.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
WB | (1) |
Use at an assay dependent concentration.
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说明 |
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ELISA
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
Neutralising
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. PubMed: 22190968 |
Flow Cyt
Use at an assay dependent concentration. ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
WB
Use at an assay dependent concentration. |
靶标
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功能
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. -
序列相似性
Belongs to the IL-1 family. -
结构域
The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. -
细胞定位
Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. - Information by UniProt
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数据库链接
- Entrez Gene: 3552 Human
- Entrez Gene: 16175 Mouse
- Omim: 147760 Human
- SwissProt: P01583 Human
- SwissProt: P01582 Mouse
- Unigene: 1722 Human
- Unigene: 15534 Mouse
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别名
- BAF antibody
- FAF antibody
- Hematopoietin 1 antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (27)
ab7632 被引用在 27 文献中.
- Vitenberga-Verza Z et al. Identification of Inflammatory and Regulatory Cytokines IL-1α-, IL-4-, IL-6-, IL-12-, IL-13-, IL-17A-, TNF-α-, and IFN-γ-Producing Cells in the Milk of Dairy Cows with Subclinical and Clinical Mastitis. Pathogens 11:N/A (2022). PubMed: 35335696
- Collier JJ et al. Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis. Mol Metab 44:101140 (2021). PubMed: 33285301
- Lu X et al. miR-335-5P contributes to human osteoarthritis by targeting HBP1. Exp Ther Med 21:109 (2021). PubMed: 33335572
- Cao H et al. Inhibition of long non-coding RNA HOXA11-AS against neuroinflammation in Parkinson's disease model via targeting miR-124-3p mediated FSTL1/NF-?B axis. Aging (Albany NY) 13:11455-11469 (2021). PubMed: 33839699
- Wang X et al. A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis. Cell Death Dis 12:402 (2021). PubMed: 33854044