Anti-IGF2抗体(ab63984)
Key features and details
- Rabbit polyclonal to IGF2
- Suitable for: WB, IHC-Fr, IHC-P
- Reacts with: Mouse
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-IGF2抗体
参阅全部 IGF2 一抗 -
描述
兔多克隆抗体to IGF2 -
宿主
Rabbit -
特异性
Mouse 20kDa IGF2 protein.Cross reacts with rat protein. Low cross reactivity was observed with human IGF2 protein. -
经测试应用
适用于: WB, IHC-Fr, IHC-Pmore details -
种属反应性
与反应: Mouse
预测可用于: Rat, Human
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免疫原
Synthetic peptide corresponding to Mouse IGF2.
Database link: P09535 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Concentration information loading... -
纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab63984于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (2) |
Use at an assay dependent concentration.
|
| IHC-Fr |
Use at an assay dependent concentration.
|
|
| IHC-P | (1) |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
WB
Use at an assay dependent concentration. |
|
IHC-Fr
Use at an assay dependent concentration. |
|
IHC-P
Use at an assay dependent concentration. |
靶标
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功能
The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. -
疾病相关
Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SIRS) [MIM:180860]. SIRS is a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. -
序列相似性
Belongs to the insulin family. -
翻译后修饰
O-glycosylated with a core 1 or possibly core 8 glycan. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 3481 Human
- Entrez Gene: 16002 Mouse
- Entrez Gene: 24483 Rat
- Omim: 147470 Human
- SwissProt: P01344 Human
- SwissProt: P09535 Mouse
- SwissProt: P01346 Rat
- Unigene: 272259 Human
see all -
别名
- C11orf43 antibody
- IGF 2 antibody
- IGF II antibody
see all
数据表及文件
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Datasheet download
文献 (3)
ab63984 被引用在 3 文献中.
- Yuan Y et al. Ligustrazine-induced microRNA-16-5p inhibition alleviates preeclampsia through IGF-2. Reproduction 160:905-917 (2020). PubMed: 33112793
- Jung S et al. Decreased expression of extracellular matrix proteins and trophic factors in the amygdala complex of depressed mice after chronic immobilization stress. BMC Neurosci 13:58 (2012). IHC-Fr ; Mouse . PubMed: 22672618
- Singh P et al. Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK. Am J Physiol Gastrointest Liver Physiol 298:G551-62 (2010). Neutralising ; Rat . PubMed: 20133951
