Anti-IGF1抗体(ab63926)
Key features and details
- Rabbit polyclonal to IGF1
- Suitable for: WB
- Reacts with: Recombinant fragment
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-IGF1抗体
参阅全部 IGF1 一抗 -
描述
兔多克隆抗体to IGF1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Recombinant fragment -
免疫原
Recombinant murine IGF1
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常规说明
This product is manufactured by BioVision, an Abcam company and was previously called 5120R IGF-I Antibody. 5120R-100 is the same size as the 100 µg size of ab63926.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab63926于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (5) |
Use a concentration of 0.5 - 4 µg/ml. Detects a band of approximately 9 kDa (predicted molecular weight: 17 kDa).
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| 说明 |
|---|
|
WB
Use a concentration of 0.5 - 4 µg/ml. Detects a band of approximately 9 kDa (predicted molecular weight: 17 kDa). |
靶标
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功能
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. -
疾病相关
Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. -
序列相似性
Belongs to the insulin family. -
细胞定位
Secreted. - Information by UniProt
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形式
There are 2 isoforms produced by alternative splicing. Isoform 1 also known as: IGF-IB; Isoform 2 also known as: IGF-IA. -
别名
- IBP1 antibody
- IGF I antibody
- IGF IA antibody
see all
图片
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Western blot - Anti-IGF1 antibody (ab63926)All lanes : Anti-IGF1 antibody (ab63926) at 4 µg/ml
Lane 1 : Recombinant
murine IGF1 at 0.25 µg
Lane 2 : Recombinant
murine IGF1 at 1 µg
Predicted band size: 17 kDa
Observed band size: 9 kDa why is the actual band size different from the predicted?
数据表及文件
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SDS download
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Datasheet download
文献 (7)
ab63926 被引用在 7 文献中.
- Liu S et al. Lonicera caerulea Berry Polyphenols Extract Alleviates Exercise Fatigue in Mice by Reducing Oxidative Stress, Inflammation, Skeletal Muscle Cell Apoptosis, and by Increasing Cell Proliferation. Front Nutr 9:853225 (2022). PubMed: 35356725
- Dodington DW et al. JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice. JCI Insight 6:N/A (2021). PubMed: 33682794
- Miyagawa K et al. Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo. JCI Insight 5:N/A (2020). PubMed: 32078587
- Rege SD et al. Brain Trauma Disrupts Hepatic Lipid Metabolism: Blame It on Fructose? Mol Nutr Food Res 63:e1801054 (2019). PubMed: 31087499
- Durham E et al. Thyroxine Exposure Effects on the Cranial Base. Calcif Tissue Int 101:300-311 (2017). PubMed: 28391432
- Garcia LA et al. 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Endocrinology 152:2976-86 (2011). WB ; Mouse . PubMed: 21673099
- Mair M et al. Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis. Gastroenterology 138:2499-508 (2010). WB . PubMed: 20193684