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AB106706

Anti-IgA抗体[KT13]

Anti-IgA antibody [KT13]

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(1 Publication)

Mouse Monoclonal IGHA1 antibody. Suitable for WB, ELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IGHA1.

查看别名

Immunoglobulin heavy constant alpha 1, Ig alpha-1 chain C region, Ig alpha-1 chain C region BUR, Ig alpha-1 chain C region TRO, IGHA1

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

KT13

亚型

IgG2a

不含载体蛋白

No

反应种属

Human

应用

ELISA, WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human IGHA1. The exact immunogen used to generate this antibody is proprietary information.

P01876

特异性

ab106706 is Fc specific and reacts with IgA1 and IgA2, but does not cross-react with Human IgG and anti-NP IgG1, IgG2, IgG3, IgG4, IgE and IgM.

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替代产品

Primary Antibodies

AB53270

Biotin Anti-IgA antibody [IgA5-3B]

  • 0
  • 0
Primary Antibodies

AB222777

Biotin Anti-IgA antibody [RM220]

Recombinant

ELISA - Biotin Anti-IgA antibody [RM220] (AB222777)

  • 0
  • 0
Primary Antibodies

AB224184

Biotin Anti-IgA antibody [RM128]

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-IgA antibody [RM128] (AB224184)

  • 0
  • 0
Primary Antibodies

AB124716

Anti-IgA antibody [EPR5367-76]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IgA antibody [EPR5367-76] (AB124716)

  • 5
  • 2
Primary Antibodies

AB214003

Anti-IgA antibody [EPR5367-76] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Anti-IgA antibody [EPR5367-76] - BSA and Azide free (AB214003)

  • 4
  • 1
Primary Antibodies

AB223410

Alexa Fluor® 488 Anti-IgA antibody [EPR5367-76]

RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Alexa Fluor® 488 Anti-IgA antibody [EPR5367-76] (AB223410)

  • 4
  • 1

搭配使用产品

Assay Kits

AB196263

Human IgA ELISA Kit

Recombinant|SimpleStep

ELISA - Human IgA ELISA Kit (AB196263)

  • 4
  • 1
Reagents, Controls & Accessories

AB7477

Normal Chicken Serum (sterile)

  • 0
  • 0
Primary Antibodies

AB197780

Anti-mouse IgG Fc antibody [RMG06]

Recombinant

ELISA - Anti-mouse IgG Fc antibody [RMG06] (AB197780)

  • 0
  • 0
Primary Antibodies

AB166970

Anti-IgG2a antibody [KT92]

  • 0
  • 0
Primary Antibodies

AB170489

HRP Anti-IgG2a antibody [KT92]

ELISA - HRP Anti-IgG2a antibody [KT92] (AB170489)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/1000 - 1/20000", "WB-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1 µg/mL", "ELISA-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
Preservative: 0.1% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Immunoglobulin A (IgA) also known as sIgA in its secretory form is an important component of the immune system. With a molecular weight of approximately 160 kDa IgA exists as a monomeric or dimeric structure. It is primarily expressed in mucosal areas such as the respiratory tract gastrointestinal tract and urogenital tract while also being present in secretions like saliva tears and breast milk. In its dimeric form IgA associates with a joining (J) chain and a secretory component which facilitates its transport across mucosal barriers.
Biological function summary

IgA functions as a first line of defense in immune responses occurring at mucosal surfaces. Its primary role is to neutralize pathogens toxins and prevent their attachment and penetration through epithelial cells. This antibody does not form part of a larger complex but plays an important role in immune exclusion by trapping antigens in the mucus layer. Additionally IgA can mediate antibody-dependent cellular cytotoxicity and engage with specific receptors like FcαRI (CD89) on immune cells further enhancing its protective capabilities.

Pathways

IgA participates in the mucosal immune response which is a sub-component of the broader immune system pathways. It is closely associated with the polymeric immunoglobulin receptor (pIgR) which transports IgA to the mucosal surfaces. The pathway involves recombination activation proteins (RAG) during its class-switching process in B cells differentiating from IgM-producing cells to those secreting IgA. These pathways are integral to maintaining the mucosal environment and protecting against pathogens.

Alterations or deficiencies in IgA can lead to increased susceptibility to infections and disorders like IgA nephropathy and celiac disease. In IgA nephropathy IgA deposits in the kidneys result in inflammation and damage to renal tissues. Celiac disease involves an immune reaction to gluten where IgA antibodies against tissue transglutaminase (tTG) contribute to intestinal damage. Both conditions illustrate the importance of IgA in maintaining immune balance and its connection with disease pathologies.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed : 20176268, PubMed : 22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed : 17576170, PubMed : 20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed : 2241915).
See full target information IGHA1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Metabolites 10: PubMed32235559

2020

Enhancing Glycolysis Protects against Ischemia-Reperfusion Injury by Reducing ROS Production.

Applications

Unspecified application

Species

Unspecified reactive species

Claudia Beltran,Rosario Pardo,Diana Bou-Teen,Marisol Ruiz-Meana,Josep A Villena,Ignacio Ferreira-González,Ignasi Barba
View all publications
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