Anti-IFNAR2抗体[KT5] (ab106644)
Key features and details
- Mouse monoclonal [KT5] to IFNAR2
- Suitable for: WB, ELISA
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-IFNAR2抗体[KT5]
参阅全部 IFNAR2 一抗 -
描述
小鼠单克隆抗体[KT5] to IFNAR2 -
宿主
Mouse -
特异性
Reacts with both IFN-alpha2a and IFN-alpha2b -
经测试应用
适用于: WB, ELISAmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein (Human)
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
KT5 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106644于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use at an assay dependent concentration.
|
|
| ELISA |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
WB
Use at an assay dependent concentration. |
|
ELISA
Use at an assay dependent concentration. |
靶标
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功能
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. -
组织特异性
Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. -
序列相似性
Belongs to the type II cytokine receptor family. -
翻译后修饰
Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
Glycosylated. -
细胞定位
Secreted and Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3455 Human
- Omim: 602376 Human
- SwissProt: P48551 Human
- Unigene: 708195 Human
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别名
- Human interferon alpha/beta receptor antibody
- IFN alpha REC antibody
- IFN R antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab106644 尚未被引用在任何文献中。