Key features and details
- Mouse monoclonal [MEM-111] to ICAM1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG2a
参阅全部 ICAM1 一抗
描述小鼠单克隆抗体[MEM-111] to ICAM1
his antibody reacts with human CD54 antigen.
经测试应用适用于: WBmore details
Tissue, cells or virus corresponding to Human ICAM1. Burkitt's lymphoma cell line RAJI
- For WB it is highly recommended to use TNF-alpha activated HUVEC cells as a positive control.
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.097% Sodium azide
Concentration information loading...
纯度Protein A purified
sELISA pair antibody
功能ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
序列相似性Belongs to the immunoglobulin superfamily. ICAM family.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
翻译后修饰Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
- Information by UniProt
- Antigen identified by monoclonal antibody BB2 antibody
- BB 2 antibody
- BB2 antibody
All lanes : Anti-ICAM1 antibody [MEM-111] (ab2213)
Lane 1 : TNF-alpha activated HUVEC (Human umbilical vein endothelial cell line) whole cell lysate
Lane 2 : TNF-alpha nonactivated HUVEC cells
Performed under non-reducing conditions.
Observed band size: 90 kDa why is the actual band size different from the predicted?
Lower bands represent tubulin as a loading control.
ab2213 被引用在 72 文献中.
- Harris AR et al. Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy. Front Oncol 12:801764 (2022). PubMed: 35372032
- Lim EJ et al. ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer. Cell Death Dis 13:417 (2022). PubMed: 35487888
- Sznurkowski JJ et al. Impact of Activation of EGFL7 within Microenvironment of High Grade Ovarian Serous Carcinoma on Infiltration of CD4+ and CD8+ Lymphocytes. Medicina (Kaunas) 58:N/A (2022). PubMed: 35630004
- Ding S et al. ICAM-1-related noncoding RNA accelerates atherosclerosis by amplifying NF-κB signaling. J Mol Cell Cardiol 170:75-86 (2022). PubMed: 35714558
- van den Braak WJP et al. Construction of a Vero Cell Line Expressing Human ICAM1 for the Development of Rhinovirus Vaccines. Viruses 14:N/A (2022). PubMed: 36298792