AB6507

Anti-HSV1 + HSV2 gD 抗体 [2C10]

Name: HSV1 + HSV2 gD抗体[2C10] (ab6507)| Abcam中文官网
Brand: Abcam Limited
SKU: AB6507
Price: 5069 CNY
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Rating: 5 (1 reviews)

Anti-HSV1 + HSV2 gD antibody [2C10]

(1 Review)

(28 Publications)

Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507) is a mouse monoclonal antibody detecting HSV1 + HSV2 gD in Western Blot, ICC/IF. Suitable for Herpes simplex virus, Human herpesvirus 2.

- Over 20 publications
- Trusted since 2001

查看别名

US6, gD, Envelope glycoprotein D

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gD antibody [2C10] (AB6507)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gD antibody [2C10] (AB6507)

Immunocytochemistry/Immunofluorescence analysis of vero cells infected with HSV1 (left) or HSV2 (right) labelled with ab6507.

Unknown

Western blot - Anti-HSV1 + HSV2 gD antibody [2C10] (AB6507)

The WB was completed using the HSV-1 Antigen and the HSV-2 Infected Cell Extract at 10 μg/cm

All lanes:

Western blot - Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507)

Observed band size: 55 kDa

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关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

2C10

亚型

IgG2a

轻链类型

kappa

不含载体蛋白

Yes

反应种属

Human herpesvirus 2, Herpes simplex virus

应用

ICC/IF, WB

applications

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Herpes simplex virus": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/3200 - 1/25600", "ICCIF-species-notes": "1/3,200 (HSV-2) - 1/25,600 (HSV-1).", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000", "WB-species-notes": "" }, "Human herpesvirus 2": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/3200 - 1/25600", "ICCIF-species-notes": "1/3,200 (HSV-2) - 1/25,600 (HSV-1).", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000", "WB-species-notes": "" } } }

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产品详情

What is this antibody validated in?
Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF) in Herpes simplex virus, Human herpesvirus 2 samples.

Trusted by the scientific community
Anti-HSV1 + HSV2 gD [2C10] (ab6507) was first used in a scientific publication in 2001 and has been cited over 20 times in peer-reviewed journals.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

HSV1 and HSV2 glycoprotein D (gD) are envelope proteins found on the surfaces of herpes simplex viruses 1 and 2. The gD protein plays a critical role in the virus life cycle by mediating entry into host cells. It binds with cellular receptors initiating membrane fusion necessary for viral entry. Glycoprotein D is approximately 38 kDa in mass and expresses mainly on the surfaces of infected cells and virion particles. These proteins serve as important targets for immune recognition and are often key in vaccine design strategies.

Biological function summary

The gD protein engages with specific cellular receptors like nectin-1 HVEM and others for initiating viral infection. This interaction facilitates the fusion of the viral envelope with the host cell membrane. Glycoprotein D is a part of the larger complex of herpesvirus envelope glycoproteins which work together to enable efficient cell entry and subsequent viral propagation. This coordination within the protein complex ensures the proper attachment and penetration of host cells.

Pathways

The gD proteins interact critically within pathways necessary for viral fusion and entry. Their relationship with proteins like glycoproteins B and H/L within the herpes virus entry mechanism is especially important. Glycoprotein B for example acts after gD-receptor binding to promote the fusion of viral and cell membranes. The fusion and entry pathway dictate the overall success of viral invasion and replication within the host organism.

Herpes simplex viruses 1 and 2 associated with the gD protein are most known for causing oral and genital herpes infections. These two forms of infection only require the presence of gD and its interaction with cellular receptors. Additionally gD is linked to herpes-related encephalitis an inflammation of brain tissue caused by the virus. The understanding of gD and its interaction with human cellular proteins offers potential therapeutic and vaccine development pathways potentially helping to manage and control herpes-related health conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Envelope glycoprotein that binds to the host cell entry receptors NECTIN1, TNFRSF14/HVEM and 3-O-sulfated heparan sulfate, promoting the virus entry into host cells (PubMed : 22146396). May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).

See full target information gD

其他靶点

gD,gD

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文献 (28)

Recent publications for all applications. Explore the full list and refine your search

Virology journal 22:249 PubMed40684179

2025

Small molecule UCM05 inhibits HSV-2 infection via targeting viral glycoproteins and fatty acid synthase with potentiating antiviral immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Songshan Li,Minghan Li,Yantong Cai,Jun Xian,Rongrong Zhu,Chan Yang,Xin Zhang,Shuya Ren,Aijiao Yu,Shuwen Liu,Bin Yang

Molecular therapy. Nucleic acids 36:102444 PubMed39897577

2025

Extracellular viral microRNAs as biomarkers of virus infection in human cells.

Applications

Unspecified application

Species

Unspecified reactive species

Cheryl Chan,Joanne Xin Yi Loh,Wei-Xiang Sin,Denise Bei Lin Teo,Nicholas Kwan Zen Tan,Chandramouli Nagarajan,Yunxin Chen,Francesca Lorraine Wei Inng Lim,Michael E Birnbaum,Rohan B H Williams,Stacy L Springs

EMBO reports 26:720-747 PubMed39747662

2025

HDAC6 deacetylates TRIM56 to negatively regulate cGAS-STING-mediated type I interferon responses.

Applications

Unspecified application

Species

Unspecified reactive species

Qiongzhen Zeng,Zixin Chen,Shan Li,Ziwei Huang,Zhe Ren,Cuifang Ye,Xiao Wang,Jun Zhou,Kaisheng Liu,Kai Zheng,Yifei Wang

Viruses 16: PubMed39205282

2024

CFTR Inhibitors Display Antiviral Activity against Herpes Simplex Virus.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Jiang,Zhong Dai,Chan Yang,Liqiong Ding,Songshan Li,Xinfeng Xu,Chen Cheng,Jinshen Wang,Shuwen Liu

Brain pathology (Zurich, Switzerland) 33:e13116 PubMed36064300

2022

Aβ plaques do not protect against HSV-1 infection in a mouse model of familial Alzheimer's disease, and HSV-1 does not induce Aβ pathology in a model of late onset Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Olga V Bocharova,Aidan Fisher,Narayan P Pandit,Kara Molesworth,Olga Mychko,Alison J Scott,Natallia Makarava,Rodney Ritzel,Ilia V Baskakov

ACS infectious diseases 8:2084-2095 PubMed36062478

2022

Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[]urils.

Applications

Unspecified application

Species

Unspecified reactive species

Luke M Jones,Elana H Super,Lauren J Batt,Matteo Gasbarri,Francesco Coppola,Lorraine M Bhebhe,Benjamin T Cheesman,Andrew M Howe,Petr Král,Roger Coulston,Samuel T Jones

Current protocols 2:e483 PubMed35822836

2022

Receptor Interactome Discovery with RDIMIS, a Membrane Protein Interaction Screen Using Recombinant Extracellular Vesicles.

Applications

Unspecified application

Species

Unspecified reactive species

Ariana D Sanchez,Sean M Peterson,Mike Reichelt,Christian M Amador,Nadia Martinez-Martin,Shengya Cao

Viruses 14: PubMed35746758

2022

Oleanolic Acid Derivative AXX-18 Exerts Antiviral Activity by Inhibiting the Expression of HSV-1 Viral Genes UL8 and UL52.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaoyang Wang,Jiaoyan Jia,Yuzhou Jiang,Feng Li,Yiliang Wang,Xiaowei Song,Shurong Qin,Yifei Wang,Kai Zheng,Binyuan Hu,Yongxian Cheng,Zhe Ren

Journal of virology 96:e0217821 PubMed35045266

2022

An ESCRT/VPS4 Envelopment Trap To Examine the Mechanism of Alphaherpesvirus Assembly and Transport in Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Jenna Barnes,Bryen A Jordan,Duncan W Wilson

Molecular biology 55:413-423 PubMed34931092

2021

Preventive Vaccination with Mesenchymal Stem Cells Protects Mice from Lethal Infection Caused by Herpes Simplex Virus 1.

Applications

Unspecified application

Species

Unspecified reactive species

R R Klimova,N A Demidova,O V Masalova,A A Kushch

View all publications

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Anti-HSV1 + HSV2 gD 抗体 [2C10]

Anti-HSV1 + HSV2 gD antibody [2C10]

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gD antibody [2C10] (AB6507)

Western blot - Anti-HSV1 + HSV2 gD antibody [2C10] (AB6507)

关键信息

宿主种属

克隆

克隆号

亚型

轻链类型

不含载体蛋白

反应种属

应用