Anti-HSP90B2P/TRAP1抗体(ab64182)
Key features and details
- Rabbit polyclonal to HSP90B2P/TRAP1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-HSP90B2P/TRAP1抗体 -
描述
兔多克隆抗体to HSP90B2P/TRAP1 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Rabbit, Cow, Dog, Pig, Xenopus laevis, Zebrafish, Cynomolgus monkey, Syrian hamster, Orangutan
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免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab64182于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use a concentration of 2.5 µg/ml.
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| 说明 |
|---|
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IHC-P
Use a concentration of 2.5 µg/ml. |
靶标
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相关性
Hsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species. Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out). One possible mechanism may be differences in post-translational modification of tumor Hsp90. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34, AHSA1, HDAC6 and SMYD3. -
细胞定位
Endoplasmic reticulum -
数据库链接
- Entrez Gene: 7190 Human
- SwissProt: Q58FF3 Human
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别名
- GRP94P1 antibody
- Heat shock protein 90kDa beta (Grp94) member 2 antibody
- HSP antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSP90B2P/TRAP1 antibody (ab64182)
ab64182 (2.5ug/ml) staining HSP90B2P/TRAP1 in human kidney tissue by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.
数据表及文件
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Datasheet download
文献 (4)
ab64182 被引用在 4 文献中.
- Wang C et al. Triangulating variation in the population to define mechanisms for precision management of genetic disease. Structure 30:1190-1207.e5 (2022). PubMed: 35714602
- Zhang L et al. TRAP1 attenuates H9C2 myocardial cell injury induced by extracellular acidification via the inhibition of MPTP opening. Int J Mol Med 46:663-674 (2020). PubMed: 32626957
- Zhu YW et al. Effect of dietary manganese on antioxidant status and expressions of heat shock proteins and factors in tissues of laying broiler breeders under normal and high environmental temperatures. Br J Nutr 116:1851-1860 (2016). PubMed: 27890044
- Zhu YW et al. Effect of dietary manganese on antioxidant status and expression levels of heat-shock proteins and factors in tissues of laying broiler breeders under normal and high environmental temperatures. Br J Nutr 114:1965-74 (2015). PubMed: 26435464
