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AB66978

Anti-HSP1 / Protamine P1 抗体

Anti-HSP1 / Protamine P1 antibody

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(1 Publication)

Mouse Polyclonal HSP1 / Protamine P1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PRM1.

查看别名

Sperm protamine P1, Cysteine-rich protamine, PRM1

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human PRM1.

P04553

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
存储溶液
pH: 7.4 Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

HSP1 / Protamine P1 also known as PRM1 is a small arginine-rich nuclear protein. It has a mass of approximately 6.3 kDa. Protamine P1 primarily expresses in the testis especially during spermatogenesis. It plays an important mechanical role in replacing histones during sperm chromatin remodeling facilitating the condensation of sperm DNA into an exceptionally compact and stable structure. This condensation is essential for protecting genetic material during transport.
Biological function summary

The protein serves a fundamental role in ensuring male fertility through its contribution to chromatin packaging. Protamine P1 does not function independently; instead it forms a complex with other protamines such as Protamine P2 (PRM2) to adequately condense the DNA in spermatids. The tight binding of Protamine P1 to DNA minimizes transcription during the final stages of sperm development preserving the genetic integrity of future offspring.

Pathways

Protamine P1's activity integrates mainly into the sperm development pathway. During this pathway it interacts closely with proteins involved in chromatin assembly and disassembly. H1 a linker histone is one such protein that transitions out of the chromatin to allow Protamine P1 to facilitate nucleosome elimination. This pathway ensures that DNA compaction and protection are achieved setting the stage for successful fertilization.

Protamine P1's role is critical in understanding male infertility and certain cases of protamine-deficiency. Abnormal expression levels or structural changes in Protamine P1 correlate with male infertility due to improper chromatin packaging. These alterations often associate with genetic problems in Protamine P2 or disruptions in the balance between the two protamines. Furthermore studies have linked Protamine P1 to increased DNA fragmentation in sperm which can contribute to unsuccessful zygote formation.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
See full target information PRM1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 38:5718-34 PubMed20460467

2010

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Deepti Malhotra,Elodie Portales-Casamar,Anju Singh,Siddhartha Srivastava,David Arenillas,Christine Happel,Casper Shyr,Nobunao Wakabayashi,Thomas W Kensler,Wyeth W Wasserman,Shyam Biswal
View all publications
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搭配使用产品

Primary Antibodies

AB190791

Anti-Protamine 2 antibody [EPR15738]

20ul selling size|RabMAb|Recombinant

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Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

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  • 16
Primary Antibodies

AB68719

Anti-HP1BP3 antibody

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  • 0
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Primary Antibodies

AB205064

Anti-GBA2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GBA2 antibody (AB205064)

  • 1
  • 2

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