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AB20686

HRP Anti-Respiratory Syncytial Virus抗体

HRP Anti-Respiratory Syncytial Virus antibody

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(3 Publications)

Anti-Respiratory Syncytial Virus antibody conjugated to HRP is a goat polyclonal antibody suitable for ELISA, IHC-P, Neut.

查看别名

RS virus, RSV

关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

偶联物

HRP

激发波长/发射波长
不含载体蛋白

No

反应种属

Respiratory syncytial virus

应用

IHC-P, ELISA, FuncS (Neut/Block)

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Respiratory syncytial virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "<p></p>" } } }

产品详情

Covalently coupled to a highly purified preparation of Horseradish Peroxidase (RZ>3). Care is taken to ensure adequate conjugation while preserving maximum enzyme activity. Free enzyme is removed.

性能和储存信息

形式
Liquid
纯度
IgG fraction
存储溶液
Preservative: 0.002% Thimerosal (merthiolate) Constituents: PBS, 1% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Respiratory Syncytial Virus (RSV) is a negative-sense single-stranded RNA virus known to cause respiratory infections. It belongs to the Paramyxoviridae family and is sometimes referred to by its alternate names like Human Orthopneumovirus. RSV is approximately 15 kb in size. It is predominantly expressed in the respiratory tract where it attacks epithelial cells leading to infection. The virus's ability to form a syncytium a large multinucleate cell is one of its mechanical strategies to aid in the spread across the host cells.
Biological function summary

The virus propagates efficiently within the host tissue leading to serious respiratory illness in infants and young children. RSV is not part of a specific complex but it engages host cellular machinery to promote its replication and prevent immune detection. The fusion (F) protein of RSV plays a critical role in mediating membrane fusion facilitating viral entry into the host cells. The involvement of viral proteins in modulating host immune responses is significant for the virus's life cycle.

Pathways

Respiratory infections caused by RSV connect to the host's immune signaling pathways including the toll-like receptor (TLR) pathways and the interferon response pathway. The interaction of RSV proteins with these pathways leads to an increased inflammatory response. Proteins such as the RSV G protein interface with the chemokine receptor pathway which helps in modulation of the immune system to allow viral persistence. These interactions demonstrate the virus's strategies to evade immune surveillance and promote infection.

Respiratory syncytial virus is a major cause of bronchiolitis and pneumonia in infants and young children. The virus's activity in the respiratory tract contributes to severe inflammation and cell damage which can lead to hospitalization. Other proteins like RSV M protein are involved in virus assembly and budding and they passively influence disease progression by impacting viral load and the host's immune response. Understanding these interactions is important for developing therapeutic strategies including anti-RSV monoclonal antibodies like palivizumab (2F7) which target prominent viral components to prevent severe disease outcomes.

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Human vaccines & immunotherapeutics :1-13 PubMed33427044

2021

A novel vaccine adjuvant based on straight polyacrylate potentiates vaccine-induced humoral and cellular immunity in cynomolgus macaques.

Applications

Unspecified application

Species

Unspecified reactive species

Vincent Pavot,Hélène Bisceglia,Florine Guillaume,Sandrine Montano,Linong Zhang,Florence Boudet,Jean Haensler

PloS one 13:e0199452 PubMed29920563

2018

Effect of genetic background and delivery route on the preclinical properties of a live attenuated RSV vaccine.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel Groppo,Joshua DiNapoli,Kwang Il Jeong,Michael Kishko,Nicholas Jackson,Harold Kleanthous,Simon Delagrave,Linong Zhang,Mark Parrington

PLoS pathogens 14:e1006935 PubMed29509814

2018

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Harrison G Jones,Tina Ritschel,Gabriel Pascual,Just P J Brakenhoff,Elissa Keogh,Polina Furmanova-Hollenstein,Ellen Lanckacker,Jehangir S Wadia,Morgan S A Gilman,R Anthony Williamson,Dirk Roymans,Angélique B van 't Wout,Johannes P Langedijk,Jason S McLellan
View all publications

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