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AB77895

HRP Anti-Myelin Basic蛋白抗体

HRP Anti-Myelin Basic Protein antibody

5

(2 Reviews)

|

(4 Publications)

Rabbit Polyclonal Myelin Basic Protein antibody - conjugated to HRP. Suitable for sELISA and reacts with Pig, Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Native Full Length Protein corresponding to Cow MBP.

查看别名

Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein

3 Images
Sandwich ELISA - HRP Anti-Myelin Basic Protein antibody (AB77895)
  • sELISA

Unknown

Sandwich ELISA - HRP Anti-Myelin Basic Protein antibody (AB77895)

Fixed Immobilized Anti-MBP (ab28541) : 2 ug/mL, 100 ul/well
Captured Antigen : Swine MBP , range from 1 to 90 ng/mL
Detection : anti-MBP HRP (ab77895), 0.25 ug/mL in 1% BSA and PBSt

Sandwich ELISA - HRP Anti-Myelin Basic Protein antibody (AB77895)
  • sELISA

Unknown

Sandwich ELISA - HRP Anti-Myelin Basic Protein antibody (AB77895)

Sandwich ELISA detection of mouse Myelin Basic Protein in the plasma with un-optimized sensitivity 0.1 ng/mL.

Sandwich ELISA - HRP Anti-Myelin Basic Protein antibody (AB77895)
  • sELISA

Unknown

Sandwich ELISA - HRP Anti-Myelin Basic Protein antibody (AB77895)

Immobilized Anti-MBP (ab28541) : range from 0.125 to 2 μg/ml, 100 μl/well
Fixed Captured Antigen : Swine MBP, 500 ng/mL
Detection : anti-MBP HRP (ab77895), 0.25 ug/mL in 1% BSA and PBSt

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

偶联物

HRP

激发波长/发射波长
不含载体蛋白

No

反应种属

Mouse, Human, Pig

应用

sELISA

applications

免疫原

Native Full Length Protein corresponding to Cow MBP.

P02687

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "1/10000", "sELISA-species-notes": "<p>To be used as detection antibody. Pair with <a href='/products/primary-antibodies/myelin-basic-protein-antibody-ab28541'>ab28541</a> - Rabbit polyclonal to Myelin Basic Protein</p>" }, "Mouse": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "1/10000", "sELISA-species-notes": "<p>To be used as detection antibody. Pair with <a href='/products/primary-antibodies/myelin-basic-protein-antibody-ab28541'>ab28541</a> - Rabbit polyclonal to Myelin Basic Protein</p>" }, "Pig": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "1/10000", "sELISA-species-notes": "<p>To be used as detection antibody. Pair with <a href='/products/primary-antibodies/myelin-basic-protein-antibody-ab28541'>ab28541</a> - Rabbit polyclonal to Myelin Basic Protein</p>" } } }
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我们推荐这个产品，因为它经常被用于相同的实验或相关的研究。

我们建议您务必查阅产品说明书，以确认其是否符合您的实验需求；若有疑问，也可联系我们的技术团队获取协助。

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产品详情

The purified antibody is conjugated to peroxidase (HRP) through reductive amination. Reductive amination with Ab/HRP ratio: 1/20.
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 6 - 8 Constituents: Tris buffered saline, 5% BSA, 2.94% Sodium citrate
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The myelin basic protein also referred to as MBP or MBP protein plays an important mechanical role in the central nervous system. It is a major component in the formation and stability of the myelin sheath which wraps around nerve fibers to ensure efficient neural signaling. The molecular weight of MBP can vary due to alternative splicing; one common form has a mass of about 18.5 kDa. MBP is expressed predominantly in oligodendrocytes within the brain and spinal cord where it helps form the myelin sheath. MBP2 is another variant that may be mentioned in some contexts.
Biological function summary

MBP is not just a passive structural element; it binds and interacts with lipids and other proteins to maintain the compact structure of the myelin sheath. MBP forms part of a complex that includes various other proteins and lipids ensuring the stability and function of myelin. Misfolding or altered expression of MBP can compromise myelin integrity affecting the insulation of neural pathways and signal transmission.

Pathways

MBP is an essential component in the pathways of myelination and neural plasticity. It plays a role in the signaling pathways that stimulate the development and maintenance of the myelin sheath. The protein interacts with other elements of the myelin sheath such as proteolipid protein (PLP) and myelin-associated glycoprotein (MAG) to coordinate its formation and repair processes.

MBP is linked closely to multiple sclerosis (MS) and other demyelinating conditions. Damage to or autoimmunity against MBP leads to the degradation of the myelin sheath contributing to the neurological symptoms in MS. The protein interacts with elements of the immune system with autoantibodies targeting MBP often found in MS patients. Another disorder associated with MBP dysfunction is Charcot-Marie-Tooth disease where abnormal MBP expression and structure can impact nerve function.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
See full target information MBP
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Cytokine 113:417-426 PubMed30539784

2018

The protective effect of rifampicin on behavioral deficits, biochemical, and neuropathological changes in a cuprizone model of demyelination.

Applications

Unspecified application

Species

Unspecified reactive species

Hamid Zahednasab,Masoumeh Firouzi,Sussan Kaboudanian-Ardestani,Zahra Mojallal-Tabatabaei,Sajad Karampour,Hossein Keyvani

International journal of stroke : official journal of the International Stroke Society 14:310-320 PubMed30196792

2018

A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology.

Applications

Unspecified application

Species

Unspecified reactive species

Catherine A Humphreys,Maurits A Jansen,Susana Muñoz Maniega,Víctor González-Castro,Cyril Pernet,Ian J Deary,Rustam Al-Shahi Salman,Joanna M Wardlaw,Colin Smith

BioMed research international 2014:926394 PubMed25276831

2014

Glatiramer acetate and nanny proteins restrict access of the multiple sclerosis autoantigen myelin basic protein to the 26S proteasome.

Applications

WB

Species

Cow

Ekaterina Kuzina,Anna Kudriaeva,Ivan Smirnov,Michael V Dubina,Alexander Gabibov,Alexey Belogurov

Annals of the rheumatic diseases 70:188-93 PubMed20736390

2010

Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities.

Applications

WB

Species

Human

Andreea Ioan-Facsinay,Hanane el-Bannoudi,Hans U Scherer,Diane van der Woude,Henri A Ménard,Maximilien Lora,Leendert A Trouw,Tom W J Huizinga,Rene E M Toes
View all publications
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Abcam Product Promise

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