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AB195193

重组HRP Anti-Mannose Receptor抗体[EPR6828(B)]

HRP Anti-Mannose Receptor antibody [EPR6828(B)]

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(1 Publication)

Rabbit Recombinant Monoclonal Mannose Receptor antibody - conjugated to HRP. Suitable for WB and reacts with Human samples. Cited in 1 publication.

查看别名

CD206, CLEC13D, CLEC13DL, MRC1L1, MRC1, Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor, Macrophage mannose receptor 1-like protein 1, hMR

1 Images
Western blot - HRP Anti-Mannose Receptor antibody [EPR6828(B)] (AB195193)
  • WB

Lab

Western blot - HRP Anti-Mannose Receptor antibody [EPR6828(B)] (AB195193)

Blocking buffer : 3% Milk Gel type : TA

All lanes:

Western blot - HRP Anti-Mannose Receptor antibody [EPR6828(B)] (ab195193) at 1/5000 dilution

All lanes:

Human Lung Tissue Lysate at 10 µg

Predicted band size: 166 kDa

Observed band size: 200 kDa

false

Exposure time: 20min

不同偶联物与剂型 (3)

  • Unconjugated

    Anti-Mannose Receptor antibody [EPR6828(B)]

  • Carrier free

    Anti-Mannose Receptor antibody [EPR6828(B)] - BSA and Azide free

  • Carrier free

    Anti-Mannose Receptor antibody [EPR6828(B)] - Low endotoxin, Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR6828(B)

亚型

IgG

偶联物

HRP

激发波长/发射波长
不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000", "WB-species-notes": "<p></p>" } } }
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产品详情

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.1% Proclin 300 Solution Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Mannose Receptor also known as CD206 or MRC1 is a type of C-type lectin receptor with a molecular weight of 175 kDa. It is expressed on the surface of macrophages and dendritic cells. This receptor binds to complex carbohydrates like mannose and fucose found on pathogen surfaces playing an important role in their recognition. Mannose Receptors act as endocytic receptors aiding in the internalization and degradation of pathogens.
Biological function summary

The Mannose Receptor functions in pathogen recognition and clearance by binding to specific carbohydrates on the pathogen's surface. It is not part of a larger molecular complex but works independently to facilitate phagocytosis. The receptor is essential in immune responses allowing macrophages and dendritic cells to efficiently capture and process antigens for presentation to T cells. This enables the initiation of adaptive immune responses.

Pathways

Researchers know that the Mannose Receptor plays an important role in immune signaling pathways particularly in antigen processing and presentation. It interacts with proteins involved in these pathways including those necessary for the internalization and degradation of bound antigens. Moreover it works alongside scavenger receptors contributing to the regulation of immune and inflammatory responses.

The Mannose Receptor is often linked to pulmonary tuberculosis and certain types of cancer. When macrophages express this receptor it can modulate immune responses against Mycobacterium tuberculosis by aiding in its recognition. In cancer altered expression of CD206 can indicate tumor-associated macrophages which promote tumor growth by suppressing immune responses. These connections highlight the receptor's potential as a diagnostic marker and therapeutic target.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.. (Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens.. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.. (Microbial infection) Interacts with Hepatitis B virus envelope protein.
See full target information MRC1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Clinical proteomics 16:34 PubMed31467500

2019

Potential early clinical stage colorectal cancer diagnosis using a proteomics blood test panel.

Applications

Unspecified application

Species

Unspecified reactive species

Seong Beom Ahn,Samridhi Sharma,Abidali Mohamedali,Sadia Mahboob,William J Redmond,Dana Pascovici,Jemma X Wu,Thiri Zaw,Subash Adhikari,Vineet Vaibhav,Edouard C Nice,Mark S Baker
View all publications
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替代产品

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搭配使用产品

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