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AB20878

HRP Anti-Hepatitis B Virus Surface Antigen (Ad/Ay) 抗体

HRP Anti-Hepatitis B Virus Surface Antigen (Ad/Ay) antibody

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(2 Publications)

Rabbit Polyclonal HBSAG antibody - conjugated to HRP. Suitable for ELISA and reacts with Hepatitis B virus samples. Cited in 2 publications.

查看别名

Large envelope protein, L glycoprotein, L-HBsAg, Large S protein, Large surface protein, Major surface antigen, LHB, S

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

偶联物

HRP

激发波长/发射波长
不含载体蛋白

No

反应种属

Hepatitis B virus

应用

ELISA

applications

特异性

Monospecific, reacts only with Hepatitis B surface antigen including the pre-S1 epitope. Non-reactive with normal human serum.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis B virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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产品详情

Estimated molar HRP:IgG substitution is 2-3.
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
纯化说明
Protein A chromatography purified IgG fraction covalently coupled to a highly purified preparation of horseradish peroxidase (RZ>3). Care is taken to ensure adequate conjugation while preserving maximum enzyme activity. Free enzyme is absent.
存储溶液
Preservative: 0.002% Thimerosal (merthiolate) Constituents: PBS, 1% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis B Virus Surface Antigen (HBsAg) also known as Hepatitis B surface antigen AD/AY serves as a significant marker for the Hepatitis B virus (HBV). This glycoprotein displays a molecular mass of approximately 24 kDa and consists of small medium and large protein forms. HBsAg is typically expressed in the infected liver cells and secreted into the bloodstream. This expression allows its use as a diagnostic marker for HBV infection through assays like HBsAg ELISA which detects the presence of the virus.
Biological function summary

The surface antigen plays an important role in the virus's attachment and entry into hepatocytes. HBsAg forms part of the viral envelope structure which facilitates the virus's ability to infect host cells. The presence of HBsAg is linked to an individual's immune response specifically the production of hepatitis antibodies. Its interaction with the host's immune system and antibodies like hep B antibodies are essential for understanding both viral pathogenesis and immunity to HBV infections.

Pathways

The Hepatitis B virus surface antigen plays critical parts in the infectious cycle and immune response pathways. One important pathway includes the endocytosis pathway where HBsAg is involved in the virus's entry into liver cells. The surface antigen also interacts with the human immune system influencing the expression of Hepatitis B antibodies. Connected proteins include those involved in the immune signaling where alterations affect the body's ability to mount an effective response against HBV.

The Hepatitis B Virus Surface Antigen is directly associated with Hepatitis B infection and its progression. Chronic HBV infection may lead to liver-related diseases such as cirrhosis and hepatocellular carcinoma. HBsAg presence serves as an indicator for diagnosing these liver diseases. The antigen's interaction with other viral proteins such as the core antigen and E antigen are important in the disease's progression and overall clinical outcomes.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.. The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
See full target information S

其他靶点

S,
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

ACS synthetic biology 12:657-663 PubMed36848292

2023

A Biological OR(XNOR) Logic Gate Couples Carbon Source and Transgene Expression Switching in a () Strain Co-producing Process-Enhancing Lipase and a Virus-like Particle (VLP) Vaccine.

Applications

Unspecified application

Species

Unspecified reactive species

Sushobhan Bandyopadhyay,Vasos Pavlika,Daniel G Bracewell,Darren N Nesbeth

Scientific reports 10:5770 PubMed32238843

2020

Digital DNA microarray generation on glass substrates.

Applications

Unspecified application

Species

Unspecified reactive species

Johannes Wöhrle,Stefan D Krämer,Philipp A Meyer,Christin Rath,Matthias Hügle,Gerald A Urban,Günter Roth
View all publications
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