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AB20757

HRP Anti-Borrelia burgdorferi抗体

HRP Anti-Borrelia burgdorferi antibody

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(1 Publication)

Rabbit Polyclonal Borrelia burgdorferi antibody - conjugated to HRP. Suitable for WB, ELISA, IHC-P and reacts with Borreliella burgdorferi samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Borrelia burgdorferi protein.

查看别名

B burgdorferi, B. burgdorferi, Lyme disease

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

偶联物

HRP

激发波长/发射波长
不含载体蛋白

No

反应种属

Borreliella burgdorferi

应用

ELISA, WB, IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Borrelia hermsii": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Borrelia parkeri": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Borreliella burgdorferi": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/20 - 1/200", "WB-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/200 - 1/1000", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Treponema pallidum": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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产品详情

Purified IgG fraction of antiserum covalently coupled to a highly purified preparation of Horseradish Peroxidase (RZ>3). Care is taken to ensure adequate conjugation while preserving maximum enzyme activity. Free enzyme is removed.
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性能和储存信息

形式
Liquid
纯度
IgG fraction
存储溶液
Preservative: 0.002% Thimerosal (merthiolate) Constituents: PBS, 1% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Borrelia burgdorferi known also as B. burgdorferi is a bacterium responsible for Lyme disease. It is a spirochete a type of bacteria distinguished by its corkscrew shape. This bacterium has a mass of approximately 1.5 million daltons. B. burgdorferi expresses surface proteins that have important roles in its survival and transmission including OspA and OspC which are key in interacting with host immune systems. These surface proteins allow Borrelia burgdorferi to adapt to different environments within tick vectors and mammalian hosts.
Biological function summary

The surface proteins of B. burgdorferi enable the bacterium to evade host immune responses. These components do not form part of a larger protein complex but they interact directly with host tissues to facilitate infection. B. burgdorferi's ability to alter its surface proteins through genetic recombination is a major factor in its persistence in host organisms. Its expression strategies enable it to adapt as a pathogen inside both the tick vector and mammalian hosts such as humans where it establishes chronic infections.

Pathways

Surface proteins like OspA and OspC play essential roles in the infection pathways used by Borrelia burgdorferi. Within the tick OspA enables adherence to tick midgut cells affecting transmission pathways when feeding. In mammals proteins like OspC assist the bacterium in evading the host's immune system contributing to pathways involving immune evasion and tissue infiltration. These protein interactions allow B. burgdorferi to exploit weaknesses in host defenses distinguishing this spirochete in bacterial pathogenesis.

Borrelia burgdorferi is directly related to Lyme disease a condition that if untreated can lead to severe neurological and arthritic symptoms. The surface protein OspC is particularly significant in early-stage Lyme disease and is a primary target for research into disease markers. In chronic cases Borrelia antibodies may not be effective leading to persistent infection. Additionally the relationship with other proteins like those in the host's immune pathways e.g. complement proteins is a current focus in understanding how B. burgdorferi achieves sustained infection in humans.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

See full target information Borrelia burgdorferi
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research & therapy 13:350 PubMed35883190

2022

Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice.

Applications

Unspecified application

Species

Unspecified reactive species

Mohamed A Ghoneim,Mahmoud M Gabr,Ayman F Refaie,Sawsan M El-Halawani,Mohga M Al-Issawi,Batoul L Elbassiouny,Mai A Abd El Kader,Amani M Ismail,Mona F Zidan,Mary S Karras,Raghda W Magar,Sherry M Khater,Sylvia A Ashamallah,Mahmoud M Zakaria,Malgorzata Kloc
View all publications
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替代产品

Primary Antibodies

AB69252

FITC Anti-Borrelia burgdorferi antibody

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Primary Antibodies

AB69219

Anti-Borrelia burgdorferi antibody

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搭配使用产品

Primary Antibodies

AB68629

HRP Anti-Treponema pallidum antibody

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Primary Antibodies

AB20118

FITC Anti-Borrelia burgdorferi antibody

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  • 0
Sample Prep & Detection Kits

AB64238

DAB Substrate Kit

Immunohistochemistry - DAB Substrate Kit (AB64238)

  • 5
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Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
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