重组Anti-HRH3/H3R抗体[S04-3I4] (ab317387)
![Western blot - Anti-HRH3/H3R Antibody [S04-3I4] (ab317387)](https://www.abcam.cn/ps/products/317/ab317387/Images/ab317387-536484-anti-hrh3h3r-antibody-s04-3i4-western-blot-k562-c6-3t3-human-rat-mouse.jpg "Western blot - Anti-HRH3/H3R Antibody [S04-3I4] (ab317387)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [S04-3I4] to HRH3/H3R
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
概述
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产品名称
Anti-HRH3/H3R抗体[S04-3I4]
参阅全部 HRH3/H3R 一抗 -
描述
兔单克隆抗体[S04-3I4] to HRH3/H3R -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide corresponding to Human HRH3/H3R.
Database link: Q9Y5N1 -
阳性对照
- WB: Jurkat, C6 and NIH/3T3 cell lysate.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.01% Sodium azide
Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA -
Concentration information loading... -
纯度
Affinity purified -
克隆
单克隆 -
克隆编号
S04-3I4 -
同种型
IgG -
研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab317387于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000. Predicted molecular weight: 49 kDa.
|
| 说明 |
|---|
|
WB
1/1000. Predicted molecular weight: 49 kDa. |
靶标
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功能
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization. -
组织特异性
Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 11255 Human
- Entrez Gene: 99296 Mouse
- Entrez Gene: 85268 Rat
- Omim: 604525 Human
- SwissProt: Q9Y5N1 Human
- SwissProt: P58406 Mouse
- SwissProt: Q9QYN8 Rat
- Unigene: 251399 Human
see all -
别名
- G protein coupled receptor 97 antibody
- G-protein coupled receptor 97 antibody
- GPCR 97 antibody
see all
图片
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Western blot - Anti-HRH3/H3R Antibody [S04-3I4] (ab317387)All lanes : Anti-HRH3/H3R Antibody [S04-3I4] (ab317387) at 1/1000 dilution
Lane 1 : K562 cell lysate
Lane 2 : C6 cell lysate
Lane 3 : NIH/3T3 cell lysate
Predicted band size: 49 kDa
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab317387 尚未被引用在任何文献中。