AB17185

Anti-HPV16 E2抗体[TVG 261]

Name: HPV16 E2抗体[TVG 261] (ab17185)| Abcam中文官网
Brand: Abcam Limited
SKU: AB17185
Price: 4863 CNY
Availability: InStock
Rating: 5 (3 reviews)

Anti-HPV16 E2 antibody [TVG 261]

(3 Reviews)

(14 Publications)

Mouse Monoclonal VE2 antibody. Suitable for ELISA, WB and reacts with Human papillomavirus type 16 samples. Cited in 14 publications.

查看别名

Regulatory protein E2, E2

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

TVG 261

亚型

IgG1

不含载体蛋白

反应种属

Human papillomavirus type 16

应用

ELISA, WB

applications

表位

aa2-17 - ETLCQRLNVCQDKILT.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human papillomavirus type 16": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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产品详情

The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. E1 and E2 are proteins involved in the regulation of viral DNA replication. TVG 261 is useful for detection of protein in cervical lesions.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A/G

存储溶液

Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.

See full target information E2

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文献 (14)

Recent publications for all applications. Explore the full list and refine your search

Journal of cancer research and clinical oncology 149:6225-6237 PubMed36700980

2023

hnRNP K induces HPV16 oncogene expression and promotes cervical cancerization.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanjing Lyu,Li Song,Rui Mao,Chunliang Liu,Meijuan Feng,Caihong Wu,Ruixin Pei,Ling Ding,Jintao Wang

Frontiers in oncology 12:905900 PubMed35800060

2022

hnRNP E1 Regulates HPV16 Oncogene Expression and Inhibits Cervical Cancerization.

Applications

Unspecified application

Species

Unspecified reactive species

Li Song,Rui Mao,Ling Ding,Zhiqiang Tian,Mingxuan Zhang,Jiahao Wang,Ming Wang,Yuanjing Lyu,Chunliang Liu,Meijuan Feng,Haixia Jia,Jintao Wang

Microbiology spectrum 10:e0068122 PubMed35608342

2022

A Critical Role for p53 during the HPV16 Life Cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Christian T Fontan,Claire D James,Apurva T Prabhakar,Molly L Bristol,Raymonde Otoa,Xu Wang,Elmira Karimi,Pavithra Rajagopalan,Devraj Basu,Iain M Morgan

mBio 12:e0116321 PubMed34544280

2021

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Apurva T Prabhakar,Claire D James,Dipon Das,Raymonde Otoa,Matthew Day,John Burgner,Christian T Fontan,Xu Wang,Sarah H Glass,Andreas Wieland,Mary M Donaldson,Molly L Bristol,Renfeng Li,Anthony W Oliver,Laurence H Pearl,Brian O Smith,Iain M Morgan

Journal of virology 93: PubMed30518656

2019

Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Michael R Evans,Claire D James,Molly L Bristol,Tara J Nulton,Xu Wang,Namsimar Kaur,Elizabeth A White,Brad Windle,Iain M Morgan

Frontiers in oncology 8:445 PubMed30370252

2018

Molecular and Functional Profiles of Exosomes From HPV(+) and HPV(-) Head and Neck Cancer Cell Lines.

Applications

Unspecified application

Species

Unspecified reactive species

Sonja Ludwig,Priyanka Sharma,Marie-Nicole Theodoraki,Monika Pietrowska,Saigopalakrishna S Yerneni,Stephan Lang,Soldano Ferrone,Theresa L Whiteside

Oncotarget 8:81892-81909 PubMed29137231

2017

An oral keratinocyte life cycle model identifies novel host genome regulation by human papillomavirus 16 relevant to HPV positive head and neck cancer.

Applications

Species

Unspecified reactive species

Michael R Evans,Claire D James,Oonagh Loughran,Tara J Nulton,Xu Wang,Molly L Bristol,Brad Windle,Iain M Morgan

Evidence-based complementary and alternative medicine : eCAM 2017:7359760 PubMed28479928

2017

Cardioprotective Effects of HuoxueAnshen Recipe against Myocardial Injuries Induced by Sleep Deprivation in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Rong Yuan,Li-Li Guo,Heng-Wen Chen,Jun-Ping Li,Zhong Chen,Ben-Jun Wei,Jie Wang

Journal of virology 91: PubMed28031358

2017

Association of Human Papillomavirus 16 E2 with Rad50-Interacting Protein 1 Enhances Viral DNA Replication.

Applications

Unspecified application

Species

Unspecified reactive species

Karen Campos-León,Kalpanee Wijendra,Abida Siddiqa,Ieisha Pentland,Katherine M Feeney,Alison Knapman,Rachel Davies,Elliot J Androphy,Joanna L Parish

Journal of virology 91: PubMed27795438

2016

The Cellular DNA Helicase ChlR1 Regulates Chromatin and Nuclear Matrix Attachment of the Human Papillomavirus 16 E2 Protein and High-Copy-Number Viral Genome Establishment.

Applications

Species

Unspecified reactive species

Leanne Harris,Laura McFarlane-Majeed,Karen Campos-León,Sally Roberts,Joanna L Parish

View all publications

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Abcam Product Promise

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Anti-HPV16 E2抗体[TVG 261]

Anti-HPV16 E2 antibody [TVG 261]

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

表位

反应性数据

产品详情

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

产品实验方案

靶点信息

文献 (14)

Abcam Product Promise

Anti-HPV16 E2抗体[TVG 261]

Anti-HPV16 E2 antibody [TVG 261]

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

表位

替代产品

Primary Antibodies

搭配使用产品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Sample Prep & Detection Kits

反应性数据

产品详情

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

产品实验方案

靶点信息

文献 (14)

Abcam Product Promise