重组Anti-HOXA13抗体[EPR10357] (ab172570)
![Western blot - Anti-HOXA13 antibody [EPR10357] (ab172570)](https://www.abcam.cn/ps/products/172/ab172570/Images/ab172570-194823-anti-hoxa13-antibody-epr10357-western-blot.jpg "Western blot - Anti-HOXA13 antibody [EPR10357] (ab172570)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR10357] to HOXA13
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-HOXA13抗体[EPR10357]
参阅全部 HOXA13 一抗 -
描述
兔单克隆抗体[EPR10357] to HOXA13 -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF,IHC-P or IP -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
Synthetic peptide within Human HOXA13 aa 250-350. The exact sequence is proprietary.
Database link: P31271 -
阳性对照
- 293T, K562 and Y79 cell lysates.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Constituents: 0.35% Sodium citrate, 0.17% Sodium chloride, 0.03% EDTA, 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR10357 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab172570于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000 - 1/10000. Detects a band of approximately 40 kDa (predicted molecular weight: 39 kDa).
|
| 说明 |
|---|
|
WB
1/1000 - 1/10000. Detects a band of approximately 40 kDa (predicted molecular weight: 39 kDa). |
应用说明
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
靶标
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功能
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. -
疾病相关
Defects in HOXA13 are the cause of hand-foot-genital syndrome (HFGS) [MIM:140000]; also known as hand-foot-uterus syndrome. The clinical features include small feet with unusually short great toes and abnormal thumbs. Females with the disorder have duplication of the genital tract.
Defects in HOXA13 are the cause of Guttmacher syndrome (GUTTS) [MIM:176305]. Guttmacher syndrome is a dominantly inherited combination of distal limb and genital tract abnormalities. It has several features in common with hand-foot-genital syndrome, including hypoplastic first digits and hypospadias. Typical features not seen in hand-foot-genital syndrome include postaxial polydactyly of the hands and uniphalangeal second toes with absent nails. -
序列相似性
Belongs to the Abd-B homeobox family.
Contains 1 homeobox DNA-binding domain. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 3209 Human
- Entrez Gene: 15398 Mouse
- Entrez Gene: 500129 Rat
- Omim: 142959 Human
- SwissProt: P31271 Human
- SwissProt: Q62424 Mouse
- Unigene: 592172 Human
- Unigene: 377086 Mouse
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形式
This protein has also been described in cytoplasm. -
别名
- Homeo box 1J antibody
- Homeo box A13 antibody
- Homeobox 1J antibody
see all
图片
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Western blot - Anti-HOXA13 antibody [EPR10357] (ab172570)All lanes : Anti-HOXA13 antibody [EPR10357] (ab172570) at 1/1000 dilution
Lane 1 : 293T cell lysate
Lane 2 : K562 cell lysate
Lane 3 : Y79 cell lysate
Lysates/proteins at 10 µg per lane.
Developed using the ECL technique.
Performed under non-reducing conditions.
Predicted band size: 39 kDa -
![Anti-HOXA13 antibody [EPR10357] (ab172570)](https://www.abcam.cn/ps/products/172/ab172570/Images/ab172570-2-benefits-of-recombinant-antibodies.png)
Anti-HOXA13 antibody [EPR10357] (ab172570)
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab172570 被引用在 1 文献中.
- Li R et al. ETS Proto-Oncogene 1 Suppresses MicroRNA-128 Transcription to Promote Osteogenic Differentiation Through the HOXA13/ß-Catenin Axis. Front Physiol 12:626248 (2021). PubMed: 33746773