Anti-HMGA2抗体(ab273014)
Key features and details
- Rabbit polyclonal to HMGA2
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-HMGA2抗体
参阅全部 HMGA2 一抗 -
描述
兔多克隆抗体to HMGA2 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide corresponding to Human HMGA2. Peptide sequence around aa. 6~10(E-G-A-G-Q) derived from Human HMGA2.
Database link: P52926 -
阳性对照
- WB: NIH3T3 and HeLa cell lysate.
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常规说明
This product is manufactured by BioVision, an Abcam company and was previously called A1638 Anti-H mgA2 Antibody. A1638-100 is the same size as the 100 µl size of ab273014.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.87% Sodium chloride, 50% Glycerol (glycerin, glycerine) -
Concentration information loading... -
纯度
Affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab273014于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/1000. Predicted molecular weight: 12 kDa.
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| 说明 |
|---|
|
WB
1/500 - 1/1000. Predicted molecular weight: 12 kDa. |
靶标
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功能
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. -
疾病相关
Note=A chromosomal aberration involving HMGA2 is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with LPP is shown in lipomas. HMGA2 is also fused with a number of other genes in lipomas.
Note=A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with LPP is detected in pulmonary chondroid hamartomas.
Note=A chromosomal aberration involving HMGA2 is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with LPP is also shown in one parosteal lipoma.
Note=A chromosomal aberration involving HMGA2 is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with RAD51L1. Chromosomal rearrangements involving HMGA2 do not seem to be the principle pathobiological mechanism in uterine leiomyoma. -
序列相似性
Belongs to the HMGA family.
Contains 3 A.T hook DNA-binding domains. -
发展阶段
Expressed predominantly during embryogenesis. -
翻译后修饰
Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 8091 Human
- Entrez Gene: 15364 Mouse
- Omim: 600698 Human
- SwissProt: P52926 Human
- SwissProt: P52927 Mouse
- Unigene: 505924 Human
- Unigene: 157190 Mouse
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别名
- HMGA 2 antibody
- BABL antibody
- High mobility group (nonhistone chromosomal) protein isoform I C antibody
see all
图片
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Western blot - Anti-HMGA2 antibody (ab273014)All lanes : Anti-HMGA2 antibody (ab273014) at 1/500 dilution
Lane 1 : NIH3T3 (mouse embryonic fibroblast cell line) whole cell lysate
Lane 2 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
Predicted band size: 12 kDa
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab273014 被引用在 1 文献中.
- Huang Y et al. Let-7b-5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2. Mol Med Rep 24:N/A (2021). PubMed: 34558637