Anti-Histone Core抗体(ab7832)
Key features and details
- Sheep polyclonal to Histone Core
- Suitable for: ELISA, IP, ICC/IF, WB
- Reacts with: Mouse, Cow, Human
- Isotype: IgG
概述
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产品名称
Anti-Histone Core抗体 -
描述
羊多克隆抗体to Histone Core -
宿主
Sheep -
特异性
The antibody binds to H1, H2B, H3 and H4. There is no evidence to suggest that the antibody can bind to H2A. -
经测试应用
适用于: ELISA, IP, ICC/IF, WBmore details -
种属反应性
与反应: Mouse, Cow, Human -
免疫原
Other Immunogen Type. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Tonsil, colon carcinoma and any other human tissues.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Concentration information loading... -
纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Isotype control
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
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| ICC/IF |
Use at an assay dependent concentration.
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| WB | (1) |
Use at an assay dependent concentration.
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| 说明 |
|---|
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ELISA
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
靶标
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相关性
In diploid eukaryotic cells, the chromatin fibers are about 20nM in diameter. They consist of two major components in equal amounts, DNA and basic proteins called histones. Histones are believed to be regularly arranged in the deep grove of the DNA helix. The recurring positive charges of the histones form electrostatic associations with the negatively charged phosphate groups of DNA making the DNA more stable and flexible. This allows for the supercoiling of the chromatin fibers. The histone core protein is an octamer consisting of 2 subunits of each of histone 2A, 2B, 3 and 4. In conjunction with the linker histone H1 and the nonhistone chromosomal proteins, it is responsible for the binding and compacting of DNA into chromatin. The sequences of the core histones are highly conserved from species to species. -
细胞定位
Nuclear
实验方案
数据表及文件
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Datasheet download
文献 (2)
ab7832 被引用在 2 文献中.
- Zheng S et al. MIR31HG promotes cell proliferation and invasion by activating the Wnt/ß-catenin signaling pathway in non-small cell lung cancer. Oncol Lett 17:221-229 (2019). PubMed: 30655759
- Li Y et al. Characterization of nucleohistone and nucleoprotamine components in the mature human sperm nucleus. Asian J Androl 10:535-41 (2008). ICC/IF ; Human . PubMed: 18478156
