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AB10829

Anti-HGF抗体[EGH2 4C12.1]

Anti-HGF antibody [EGH2 4C12.1]

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(1 Publication)

Mouse Monoclonal HGF antibody. Suitable for sELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HGF.

查看别名

HPTA, HGF, Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF

1 Images
Sandwich ELISA - Anti-HGF antibody [EGH2 4C12.1] (AB10829)
  • sELISA

Unknown

Sandwich ELISA - Anti-HGF antibody [EGH2 4C12.1] (AB10829)

Standard Curve for HGF (Analyte : ab632) dilution range 1pg/ml to 1ug/ml using Capture Antibody Mouse monoclonal [EGH2 4C12.1] to HGF (ab10829) at 5ug/ml and Detector Antibody Rabbit polyclonal to HGF (ab24865) at 0.5ug/ml.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

EGH2 4C12.1

亚型

IgG2b

不含载体蛋白

No

反应种属

Human

应用

sELISA

applications

免疫原

Recombinant Fragment Protein within Human HGF. The exact immunogen used to generate this antibody is proprietary information.

P14210

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替代产品

Primary Antibodies

AB24865

Anti-HGF antibody

Sandwich ELISA - Anti-HGF antibody (AB24865)

  • 4
  • 2
Primary Antibodies

AB216623

Anti-HGF antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HGF antibody (AB216623)

  • 0
  • 0
Primary Antibodies

AB178395

Anti-HGF antibody [EPR12230]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-HGF antibody [EPR12230] (AB178395)

  • 0
  • 0
Primary Antibodies

AB240204

Anti-HGF antibody [EPR12230] - BSA and Azide free

RabMAb|Recombinant

Immunoprecipitation - Anti-HGF antibody [EPR12230] - BSA and Azide free (AB240204)

  • 0
  • 0
Primary Antibodies

AB118871

Anti-HGF antibody [7-2]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HGF antibody [7-2] (AB118871)

  • 0
  • 0

搭配使用产品

Assay Kits

AB275901

Human HGF ELISA Kit (Hepatocyte Growth Factor)

Recombinant|SimpleStep

ELISA - Human HGF ELISA Kit (Hepatocyte Growth Factor) (AB275901)

  • 0
  • 0
Primary Antibodies

AB285154

Anti-Osteoprotegerin antibody [EPR20998-279] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-Osteoprotegerin antibody [EPR20998-279] - BSA and Azide free (Detector) (AB285154)

  • 0
  • 0
Assay Kits

AB275901

Human HGF ELISA Kit (Hepatocyte Growth Factor)

Recombinant|SimpleStep

ELISA - Human HGF ELISA Kit (Hepatocyte Growth Factor) (AB275901)

  • 0
  • 0
Primary Antibodies

AB208687

Anti-FGF2 antibody [EPR20145-219]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-FGF2 antibody [EPR20145-219] (AB208687)

  • 5
  • 3
Primary Antibodies

AB269404

Anti-MMP3 antibody [EPR22308-10] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-MMP3 antibody [EPR22308-10] - BSA and Azide free (Capture) (AB269404)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "5 µg/mL", "sELISA-species-notes": "<p>For sandwich ELISA, use this antibody as Capture at 5μg/ml with <a href='/products/primary-antibodies/hgf-antibody-ab24865'>ab24865</a> as Detection.</p>" } } }
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产品详情

Plasminogen related growth factors are potent effectors of growth, movement and differentiation of epithelia and endothelia. Membrane receptor for HGF/SF is the product of the proto-oncogene c-met a tyrosine kinase.
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
Preservative: 0.02% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The hepatocyte growth factor (HGF) also known as scatter factor (SF) is a protein with a mass of approximately 83 kDa. This protein is mostly expressed in the liver but it can also be found in other organs such as the kidney and the lungs. HGF acts mechanically by binding to the c-Met receptor activating intracellular signaling mechanisms necessary for various physiological processes. Researchers often use HGF ELISA kits to measure its levels in biological samples and study its various roles.
Biological function summary

HGF plays an essential role in cellular growth regeneration and healing processes across different tissues. It is not part of a complex but functions as a single-chain polypeptide that undergoes cleavage into its active form. HGF facilitates cell proliferation and migration; this is especially important during organ regeneration and repair processes. By engaging with its receptor c-Met it induces cell survival and cytoskeletal reorganization making it important for wound healing.

Pathways

HGF is critical in the MAPK and PI3K-Akt signaling pathways which impact processes like cell division and survival. Through these pathways HGF interacts with other proteins such as ERK and Akt contributing to the regulation of cellular growth and metabolism. HGF's role in these pathways highlights its importance in developmental processes and tissue homeostasis.

HGF displays significant connections to cancer and liver cirrhosis. Its overexpression can lead to the development of various carcinomas due to its effect on cell proliferation and migration. In liver cirrhosis the altered HGF-c-Met signaling might contribute to the disease progression and hepatic dysfunction. Additionally HGF can interact with proteins such as transforming growth factor-beta (TGF-β) in these conditions influencing the pathological environment.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed : 20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (PubMed : 15167892, PubMed : 20977675). Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed : 20977675).
See full target information HGF
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 13:2876-2882 PubMed28587353

2017

Clinical analysis of the effect of anti-allergy treatment on pocket-related complications following pacemaker implantation.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Bai,Jialin Duan,Lin Wang,Rong Bai,Li Lin
View all publications
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