AB118871

Anti-HGF抗体[7-2]

Name: HGF抗体[7-2] (ab118871)| Abcam中文官网
Brand: Abcam Limited
SKU: AB118871
Price: 4519 CNY
Availability: InStock

Anti-HGF antibody [7-2]

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(3 Publications)

Mouse Monoclonal HGF antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human HGF.

查看别名

HPTA, HGF, Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HGF antibody [7-2] (AB118871)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HGF antibody [7-2] (AB118871)

Immunohistochemical of Paraffin-embedded Human cerebellum, white matter tissue labelled with ab118871 at 10 μg/ml

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HGF antibody [7-2] (AB118871)

Paraffin-embedded Human breast tissue labelled with ab118871 at 10 μg/ml.

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

7-2

亚型

IgG2a

轻链类型

kappa

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

Native Full Length Protein corresponding to Human HGF.

P14210

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

存储溶液

Preservative: 0.01% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The hepatocyte growth factor (HGF) also known as scatter factor (SF) is a protein with a mass of approximately 83 kDa. This protein is mostly expressed in the liver but it can also be found in other organs such as the kidney and the lungs. HGF acts mechanically by binding to the c-Met receptor activating intracellular signaling mechanisms necessary for various physiological processes. Researchers often use HGF ELISA kits to measure its levels in biological samples and study its various roles.

Biological function summary

HGF plays an essential role in cellular growth regeneration and healing processes across different tissues. It is not part of a complex but functions as a single-chain polypeptide that undergoes cleavage into its active form. HGF facilitates cell proliferation and migration; this is especially important during organ regeneration and repair processes. By engaging with its receptor c-Met it induces cell survival and cytoskeletal reorganization making it important for wound healing.

Pathways

HGF is critical in the MAPK and PI3K-Akt signaling pathways which impact processes like cell division and survival. Through these pathways HGF interacts with other proteins such as ERK and Akt contributing to the regulation of cellular growth and metabolism. HGF's role in these pathways highlights its importance in developmental processes and tissue homeostasis.

HGF displays significant connections to cancer and liver cirrhosis. Its overexpression can lead to the development of various carcinomas due to its effect on cell proliferation and migration. In liver cirrhosis the altered HGF-c-Met signaling might contribute to the disease progression and hepatic dysfunction. Additionally HGF can interact with proteins such as transforming growth factor-beta (TGF-β) in these conditions influencing the pathological environment.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed : 20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (PubMed : 15167892, PubMed : 20977675). Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed : 20977675).

See full target information HGF

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Immunity, inflammation and disease 11:e816 PubMed36988250

2023

NCR negative group 3 innate lymphoid cell (NCR ILC3) participates in abnormal pathology of lung in cigarette smoking-induced COPD mice.

Applications

Unspecified application

Species

Unspecified reactive species

Shuyuan Chu,Libing Ma,Xia Yang,Bo Xiao,Yaxi Liang,Shaojie Zheng,Linqiao Li

Frontiers in oncology 12:905212 PubMed36072807

2022

Development and validation of a novel fibroblast scoring model for lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shiyou Wei,Xuyu Gu,Wentian Zhang

Cancers 14: PubMed35205843

2022

c-Met and EPHA7 Receptor Tyrosine Kinases Are Related to Prognosis in Clear Cell Renal Cell Carcinoma: Focusing on the Association with Myoferlin Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Minsun Jung,Seokhyeon Lee,Kyung Chul Moon

View all publications

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Abcam Product Promise

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Anti-HGF抗体[7-2]

Anti-HGF antibody [7-2]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HGF antibody [7-2] (AB118871)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HGF antibody [7-2] (AB118871)

关键信息

宿主种属

克隆

克隆号

亚型

轻链类型

不含载体蛋白

反应种属

应用

免疫原