抗丙型肝炎病毒Core 1b抗体[C7-50] (ab2740)
Key features and details
- Mouse monoclonal [C7-50] to Hepatitis C Virus Core 1b
- Suitable for: IP, Flow Cyt, ELISA, WB
- Reacts with: Hepatitis C virus
- Isotype: IgG1
概述
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产品名称
抗丙型肝炎病毒Core 1b抗体[C7-50] -
描述
小鼠单克隆抗体[C7-50] to丙型肝炎病毒Core 1b -
宿主
Mouse -
特异性
Detects hepatitis C virus (HCV) core protein from transfected human and primate cell lines. -
经测试应用
适用于: IP, Flow Cyt, ELISA, WBmore details -
种属反应性
与反应: Hepatitis C virus -
免疫原
Recombinant full length protein (GST-tag) corresponding to Hepatitis C Virus Core 1b.
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表位
This antibody recognizes an epitope between amino acid residues 21-40 of HCV core protein. This sequence is conserved among different HCV strains. -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
C7-50 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IP |
Use at an assay dependent concentration.
|
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| Flow Cyt |
1/100.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
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| ELISA |
Use at an assay dependent concentration.
|
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| WB | (1) |
Use a concentration of 1 µg/ml.
This antibody detects a single ~21 kDa protein representing HCV core protein in various transfected cell lines. |
| 说明 |
|---|
|
IP
Use at an assay dependent concentration. |
|
Flow Cyt
1/100. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
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ELISA
Use at an assay dependent concentration. |
|
WB
Use a concentration of 1 µg/ml. This antibody detects a single ~21 kDa protein representing HCV core protein in various transfected cell lines. |
靶标
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相关性
HCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. The N terminus of the core protein is involved in transcriptional repression. There are over 20 different subtypes of Hepatitis C Virus; HCV type 1b is mostly found in Europe and Asia. The prevalence of HCV type 1b infection has recently decreased, although it still accounts for most HCV-related cirrhosis and hepatocellular carcinoma. High HCV viremia levels and HCV genotype type 1b are independent predictors for poor response to interferon-alpha therapy. HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). Therefore, it is a prime candidate for a component of a potential HCV vaccine. -
细胞定位
Secreted; Host endoplasmic reticulum membrane; Single-pass membrane protein; Host nucleus; Host cytoplasm. -
数据库链接
- Entrez Gene: 951475 Hepatitis C virus
- SwissProt: P26662 Hepatitis C virus
- SwissProt: P26663 Hepatitis C virus
- SwissProt: Q9WMX2 Hepatitis C virus
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别名
- Capsid protein C antibody
- Core protein p19 antibody
- Core protein p21 antibody
- Hepatitis C virus core protein antibody
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (91)
ab2740 被引用在 91 文献中.
- Raheja H et al. Hepatitis C virus non-structural proteins modulate cellular kinases for increased cytoplasmic abundance of host factor HuR and facilitate viral replication. PLoS Pathog 19:e1011552 (2023). PubMed: 37540723
- Miyamoto D et al. Protein tyrosine kinase Abl promotes hepatitis C virus particle assembly via interaction with viral substrate activator NS5A. J Biol Chem 298:101804 (2022). PubMed: 35257746
- Zhao J et al. An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA. Nat Commun 13:2079 (2022). PubMed: 35440123
- Liu S et al. Enhanced host immune responses in presence of HCV facilitate HBV clearance in coinfection. Virol Sin 37:408-417 (2022). PubMed: 35523417
- Anwar MI et al. PPP2R5D promotes hepatitis C virus infection by binding to viral NS5B and enhancing viral RNA replication. Virol J 19:118 (2022). PubMed: 35836293