AB2741

Anti-Hepatitis B Virus X antigen 抗体 [X36C]

Name: Hepatitis B Virus X antigen抗体[X36C] (ab2741)| Abcam中文官网
Brand: Abcam Limited
SKU: AB2741
Price: 5014 CNY
Availability: InStock

Anti-Hepatitis B Virus X antigen antibody [X36C]

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(23 Publications)

Mouse Monoclonal Protein X antibody. Suitable for IP, ELISA, WB, IHC-P and reacts with Hepatitis B virus samples. Cited in 23 publications.

查看别名

HBV X antigen, HBx, HBxAg

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

X36C

亚型

IgG1

不含载体蛋白

反应种属

Hepatitis B virus

应用

IP, ELISA, IHC-P, WB

applications

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry paraffin embedded sections", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis B virus": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯度

undefined HPTLC

存储溶液

Preservative: 0.05% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Hepatitis B Virus X antigen also known as HBx protein or hepatitis X has a molecular mass of approximately 17 kDa. This antigen is expressed in liver cells or hepatocytes infected with the hepatitis B virus (HBV). HBx protein plays an important role in the replication and pathogenesis of HBV influencing the virus lifecycle and its ability to cause liver disease. Additionally anti-HBx antibodies such as 'anti HBx' and '3f6' are significant for research and diagnostic purposes due to their binding specificity.

Biological function summary

The function of HBx protein is to modulate various cellular processes to benefit the virus. HBx is not part of a larger protein complex but it interacts with host cell pathways to promote viral replication and survival. It influences transcriptional activation cell cycle progression and apoptosis. By hijacking the host cellular machinery HBx protein enhances viral replication and contributes to chronic infection.

Pathways

The activity of HBx protein impacts critical cellular signaling networks. HBx can activate the NF-kB signaling pathway which plays a role in immune response and inflammation. Additionally HBx influences the Wnt/β-catenin signaling pathway affecting cell proliferation and differentiation. Through these pathways HBx interacts with multiple other proteins including c-Myc and p53 impacting cellular homeostasis and contributing to oncogenic potential.

HBx protein is associated with hepatitis B-related liver diseases and the development of hepatocellular carcinoma (HCC). HBx contributes significantly to the progression from chronic hepatitis B infection to liver cirrhosis and HCC. The protein affects tumor suppressors like p53 further enhancing its role in carcinogenesis. Understanding HBx’s mechanisms continues to be important for developing therapeutics and diagnostics aimed at treating HBV-related diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information Hepatitis B Virus X antigen

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文献 (23)

Recent publications for all applications. Explore the full list and refine your search

Cancer research 85:660-674 PubMed39652575

2024

HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Rigney E Turnham,Adriana Pitea,Gwendolyn M Jang,Zhong Xu,Huat Chye Lim,Alex L Choi,John Von Dollen,Rebecca S Levin,James T Webber,Elizabeth McCarthy,Junjie Hu,Xiaolei Li,Li Che,Ananya Singh,Alex Yoon,Gary K L Chan,Robin K Kelley,Danielle L Swaney,Wei Zhang,Sourav Bandyopadhyay,Fabian J Theis,Manon Eckhardt,Xin Chen,Kevan M Shokat,Trey Ideker,Nevan J Krogan,John D Gordan

Frontiers in pharmacology 15:1327149 PubMed38444939

2024

Exosomal miR-223-3p from bone marrow mesenchymal stem cells targets HDAC2 to downregulate STAT3 phosphorylation to alleviate HBx-induced ferroptosis in podocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Yueqi Chen,Xiaoqian Yang,Moxuan Feng,Yani Yu,Yongzheng Hu,Wei Jiang

Cellular and molecular gastroenterology and hepatology 17:219-235 PubMed37879404

2023

Oncostatin M Induces IFITM1 Expression to Inhibit Hepatitis B Virus Replication Via JAK-STAT Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yuchen Ye,Ya Fu,Caorui Lin,Ye Shen,Qingqing Yu,Xiaobao Yao,Qunfang Huang,Can Liu,Yongbin Zeng,Tianbin Chen,Songhang Wu,Zhen Xun,Qishui Ou

Journal of translational medicine 21:625 PubMed37715221

2023

Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Wensheng Deng,Jiaoyu Ai,Wanlin Zhang,Zhenyu Zhou,Muqi Li,Likun Yan,Lidong Zhang,Zongjing Huang,Ziyi Wu,Junhua Ai,Hai Jiang

JHEP reports : innovation in hepatology 5:100849 PubMed37701334

2023

JMJD2D stabilises and cooperates with HBx protein to promote HBV transcription and replication.

Applications

Unspecified application

Species

Unspecified reactive species

Xu Kong,Zuofeng Liu,Ruyi Zhang,Fu'an Xie,Rubing Liang,Yong Zhang,Lingling Yu,Wensheng Yang,Xi Li,Qiang Chen,Bei Li,Yilin Hong,Ming Li,Xiaogang Xia,Lingwei Gu,Lijuan Fu,Xiaohua Li,Ye Shen,Ting Wu,Chundong Yu,Wengang Li

Virus research 329:199094 PubMed36933835

2023

A novel anti-HBV agent, E-CFCP, restores Hepatitis B virus (HBV)-induced senescence-associated cellular marker perturbation in human hepatocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Yuki Takamatsu,Sanae Hayashi,Hiroki Kumamoto,Shuhei Imoto,Yasuhito Tanaka,Hiroaki Mitsuya,Nobuyo Higashi-Kuwata

Emerging microbes & infections 11:2486-2501 PubMed36102940

2022

Compartmentalisation of Hepatitis B virus X gene evolution in hepatocellular carcinoma microenvironment and the genotype-phenotype correlation of tumorigenicity in HBV-related patients with hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ya Fu,Fengling Fang,Hongyan Guo,Xialin Xiao,Yuhai Hu,Yongbin Zeng,Tianbin Chen,Songhang Wu,Ni Lin,Jinlan Huang,Ling Jiang,Qishui Ou,Can Liu

Infection and drug resistance 15:961-973 PubMed35299854

2022

Inhibition of Protease Activated Receptor 2 Attenuates HBx-Induced Inflammation and Mitochondria Oxidative Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Li,Yonggang Li,Shuhua Li,Hongwei Li,Ling Liu,Yao Xu

Journal of immunology (Baltimore, Md. : 1950) 208:672-684 PubMed35022275

2022

Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-β1-Induced OCT4/Nanog Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wenting Li,Xiaoqiong Duan,Chuanlong Zhu,Xiao Liu,Andre J Jeyarajan,Min Xu,Zeng Tu,Qiuju Sheng,Dong Chen,Chuanwu Zhu,Tuo Shao,Zhimeng Cheng,Shadi Salloum,Esperance A Schaefer,Annie J Kruger,Jacinta A Holmes,Raymond T Chung,Wenyu Lin

Experimental and therapeutic medicine 22:1211 PubMed34584556

2021

HBxAg promotes HBV replication and EGFR activation in human placental trophoblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Yayun Lin,Yan Liu,Dongping Xu,Fanfan Guo,Wentao Zhang,Yidan Zhang,Guiqin Bai

View all publications

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Anti-Hepatitis B Virus X antigen 抗体 [X36C]

Anti-Hepatitis B Virus X antigen antibody [X36C]

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

反应性数据

性能和储存信息

形式

纯度

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (23)

Abcam Product Promise

Anti-Hepatitis B Virus X antigen 抗体 [X36C]

Anti-Hepatitis B Virus X antigen antibody [X36C]

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

替代产品

Primary Antibodies

Primary Antibodies

搭配使用产品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Secondary Antibodies

反应性数据

性能和储存信息

形式

纯度

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (23)

Abcam Product Promise