AB39716

Anti-Hepatitis B Virus X antigen 抗体

Name: Hepatitis B Virus X antigen抗体 (ab39716)| Abcam中文官网
Brand: Abcam Limited
SKU: AB39716
Price: 4900 CNY
Availability: InStock
Rating: 3 (1 reviews)

Anti-Hepatitis B Virus X antigen antibody

(1 Review)

(40 Publications)

Anti-Hepatitis B Virus X antigen antibody (ab39716) is a rabbit polyclonal antibody detecting Hepatitis B Virus X antigen in Western Blot, IP, ELISA. Suitable for Hepatitis B virus.

- Over 30 publications
- Trusted since 2006

查看别名

HBV X antigen, HBx, HBxAg

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Hepatitis B virus

应用

ELISA, WB, IP

applications

特异性

The amino acid sequence of the recombinant human Hepatitis B Protein X is 100% homologous to the amino acid sequence of the natural Hepatitis B Protein X.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis B virus": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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产品详情

What is this antibody validated in?
Anti-Hepatitis B Virus X antigen antibody (ab39716) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), ELISA in Hepatitis B virus samples.

What is the molecular weight of Hepatitis B Virus X antigen?
Anti-Hepatitis B Virus X antigen (ab39716) specifically detects a band for Hepatitis B Virus X antigen (UniProt: P12936) at a molecular weight of 17kDa.

Trusted by the scientific community
Anti-Hepatitis B Virus X antigen (ab39716) was first used in a scientific publication in 2006 and has been cited over 30 times in peer-reviewed journals.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Constituents: PBS, 0.58% Sodium chloride

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Hepatitis B Virus X antigen also known as HBx protein or hepatitis X has a molecular mass of approximately 17 kDa. This antigen is expressed in liver cells or hepatocytes infected with the hepatitis B virus (HBV). HBx protein plays an important role in the replication and pathogenesis of HBV influencing the virus lifecycle and its ability to cause liver disease. Additionally anti-HBx antibodies such as 'anti HBx' and '3f6' are significant for research and diagnostic purposes due to their binding specificity.

Biological function summary

The function of HBx protein is to modulate various cellular processes to benefit the virus. HBx is not part of a larger protein complex but it interacts with host cell pathways to promote viral replication and survival. It influences transcriptional activation cell cycle progression and apoptosis. By hijacking the host cellular machinery HBx protein enhances viral replication and contributes to chronic infection.

Pathways

The activity of HBx protein impacts critical cellular signaling networks. HBx can activate the NF-kB signaling pathway which plays a role in immune response and inflammation. Additionally HBx influences the Wnt/Β-catenin signaling pathway affecting cell proliferation and differentiation. Through these pathways HBx interacts with multiple other proteins including c-Myc and p53 impacting cellular homeostasis and contributing to oncogenic potential.

HBx protein is associated with hepatitis B-related liver diseases and the development of hepatocellular carcinoma (HCC). HBx contributes significantly to the progression from chronic hepatitis B infection to liver cirrhosis and HCC. The protein affects tumor suppressors like p53 further enhancing its role in carcinogenesis. Understanding HBx’s mechanisms continues to be important for developing therapeutics and diagnostics aimed at treating HBV-related diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information Hepatitis B Virus X antigen

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文献 (40)

Recent publications for all applications. Explore the full list and refine your search

Virology journal 22:189 PubMed40500754

2025

Lamin A/C promotes HBV transcription by modulating histone modification associated with cccDNA minichromosome in an HBx-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Linshan Jiang,Lanlang Peng,Hong Chen,Fangli Liao,Liping Yang,Yuanyuan Ye,Gaoli Zhang,Hua Sun,Qin Hu,Weixian Chen

Cancer medicine 14:e70916 PubMed40476478

2025

Hepatitis B Virus X Protein Upregulates SREBP2 to Modulate Autophagy in Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qiuyan Lin,Yongxu Lin,Yongzhu Huang,Mingrong Wang,Xiaoxia Xie,Weiqi Cai,Qilan Guo,Pingying Jiang,Yuanlin Qi,Dan Li

Journal of biomedical science 31:34 PubMed38561844

2024

Significance of hepatitis B virus capsid dephosphorylation via polymerase.

Applications

Unspecified application

Species

Unspecified reactive species

Chih-Hsu Chang,Chiaho Shih

Journal of virology 97:e0128723 PubMed37800948

2023

Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication.

Applications

Unspecified application

Species

Unspecified reactive species

Adi Ariffianto,Lin Deng,Takayuki Abe,Chieko Matsui,Masahiko Ito,Akihide Ryo,Hussein Hassan Aly,Koichi Watashi,Tetsuro Suzuki,Masashi Mizokami,Yoshiharu Matsuura,Ikuo Shoji

BMC cancer 23:593 PubMed37370037

2023

Integrated analysis of intratumoral biomarker and tumor-associated macrophage to improve the prognosis prediction in cancer patients.

Applications

Unspecified application

Species

Unspecified reactive species

Ming-Da Wang,Hao Xiang,Tian-Yu Hong,Abudurexiti Mierxiati,Fei-Hu Yan,Ling Zhang,Chao Wang

Frontiers in pharmacology 14:1159094 PubMed37361218

2023

Exploring the mechanism of JiGuCao capsule formula on treating hepatitis B virus infection via network pharmacology analysis and experiment verification.

Applications

Unspecified application

Species

Unspecified reactive species

Xu Cao,Ningyi Zhang,Hening Chen,Wei Wang,Yijun Liang,Jiaxin Zhang,Ruijia Liu,Shuo Li,Yuhao Yao,Qian Jin,Ziwei Guo,Yue Chen,Yuanyuan Gong,Xiaoke Li,Xiaobin Zao,Yong'an Ye

World journal of gastroenterology 28:4812-4822 PubMed36156926

2022

Previous hepatitis B viral infection-an underestimated cause of pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Sergey Batskikh,Sergey Morozov,Alexey Dorofeev,Zanna Borunova,Dmitry Kostyushev,Sergey Brezgin,Anastasiya Kostyusheva,Vladimir Chulanov

Biochemistry and biophysics reports 32:101352 PubMed36160029

2022

HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Chiyumi Oda,Kenya Kamimura,Osamu Shibata,Shinichi Morita,Yuto Tanaka,Toru Setsu,Hiroyuki Abe,Takeshi Yokoo,Akira Sakamaki,Hiroteru Kamimura,Satoshi Kofuji,Toshifumi Wakai,Hiroshi Nishina,Shuji Terai

Viruses 14: PubMed36146694

2022

HBx 128-133 Deletion Affecting HBV Mother-to-Child Transmission Weakens HBV Replication via Reducing HBx Level and CP/ENII Transcriptional Activity.

Applications

Unspecified application

Species

Unspecified reactive species

Yarong Song,Ying Lu,Yi Li,Minmin Liu,Hui Zhuang,Jie Li,Jie Wang

Cellular and molecular gastroenterology and hepatology 14:1177-1198 PubMed35987451

2022

cccDNA Surrogate MC-HBV-Based Screen Identifies Cohesin Complex as a Novel HBV Restriction Factor.

Applications

Unspecified application

Species

Unspecified reactive species

Zhuanchang Wu,Liyuan Wang,Xin Wang,Yang Sun,Haoran Li,Zhaoying Zhang,Caiyue Ren,Xiaohui Zhang,Shuangjie Li,Jinghui Lu,Leiqi Xu,Xuetian Yue,Yue Hong,Qiang Li,Haizhen Zhu,Yaoqin Gong,Chengjiang Gao,Huili Hu,Lifen Gao,Xiaohong Liang,Chunhong Ma

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Hepatitis B Virus X antigen 抗体

Anti-Hepatitis B Virus X antigen antibody

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

特异性

反应性数据

产品详情

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (40)

Abcam Product Promise

Anti-Hepatitis B Virus X antigen 抗体

Anti-Hepatitis B Virus X antigen antibody

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

特异性

替代产品

Primary Antibodies

Primary Antibodies

搭配使用产品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

反应性数据

产品详情

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

文献 (40)

Abcam Product Promise