AB48135

Anti-Hemopexin抗体

Name: Hemopexin抗体 (ab48135)| Abcam中文官网
Brand: Abcam Limited
SKU: AB48135
Price: 4829 CNY
Availability: InStock

Anti-Hemopexin antibody

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(1 Publication)

Rabbit Polyclonal Hemopexin antibody. Suitable for sELISA and reacts with Purified native protein - Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human Hemopexin.

查看别名

Hemopexin, Beta-1B-glycoprotein, HPX

1 Images

Sandwich ELISA - Anti-Hemopexin antibody (AB48135)

sELISA

Unknown

Sandwich ELISA - Anti-Hemopexin antibody (AB48135)

Standard Curve for Hemopexin (Analyte : Hemopexin protein (ab98988)); dilution range 1pg/ml to 1μg/ml using Capture Antibody Mouse monoclonal [32] to Hemopexin (ab27711) at 5μg/ml and Detector Antibody Rabbit polyclonal to Hemopexin (ab48135) at 0.5μg/ml.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

sELISA

applications

免疫原

Native Full Length Protein corresponding to Human Hemopexin.

P02790

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "predicted", "sELISA-species-dilution-info": "", "sELISA-species-notes": "" }, "Purified native protein - Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p>For sandwich ELISA, use this antibody as Detection at 0.5 µg/ml with Mouse monoclonal [32] to Hemopexin (<a href='/products/primary-antibodies/hemopexin-antibody-32-ab27711'>ab27711</a>) as Capture.</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Hemopexin also known as HPX is a glycoprotein that transports heme in the blood. It has a molecular weight of approximately 57 kDa and is primarily expressed in the liver. Hemopexin binds to free heme with high affinity which prevents oxidative damage and conserves iron. It transports the heme to hepatocytes for breakdown and recycling protecting cells from iron-mediated toxicity and oxidative stress.

Biological function summary

The hemopexin function relates to protecting tissues from the harmful effects of free heme. Hemopexin does not work as part of a complex in this process but mainly acts independently. Its high binding affinity plays an important role in maintaining heme homeostasis in the plasma and tissues. By controlling heme levels hemopexin supports overall cellular health and function.

Pathways

The hemopexin molecular weight allows it to fit effectively within the heme metabolism and iron recycling pathways. This protein plays a significant role by delivering heme to the liver and facilitating its degradation by heme oxygenase. Hemopexin interacts closely with heme oxygenase and albumin two proteins important for the management of heme and iron levels in the body.

Several hemopexin functions contribute to the understanding of conditions such as hemolytic anemia and acute liver injury. In hemolytic anemia hemopexin helps mitigate the effects of increased heme levels due to excessive red blood cell breakdown. In the context of liver injury the protein assists in the detoxification process and supports hepatic function. Hemopexin-related proteins such as heme oxygenase link these diseases to hemopexin by their roles in managing oxidative stress and heme catabolism.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

See full target information Hemopexin

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 47:6130-6144 PubMed31037292

2019

Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Tongxing Song,Yang Yang,Hongkui Wei,Xiaowei Xie,Jinxin Lu,Qianhui Zeng,Jie Peng,Yuanfei Zhou,Siwen Jiang,Jian Peng

View all publications

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Anti-Hemopexin抗体

Anti-Hemopexin antibody

Sandwich ELISA - Anti-Hemopexin antibody (AB48135)