AB50967

Anti-heavy chain cardiac Myosin 抗体 [BA-G5]

Name: heavy chain cardiac Myosin抗体[BA-G5] (ab50967)| Abcam中文官网
Brand: Abcam Limited
SKU: AB50967
Price: 1559 CNY
Availability: InStock
Rating: 4 (12 reviews)

Anti-heavy chain cardiac Myosin antibody [BA-G5]

(12 Reviews)

(112 Publications)

Mouse Monoclonal MYH7 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 112 publications.

查看别名

Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, MyHC-beta, Myh7

2 Images

Unknown

Western blot - Anti-heavy chain cardiac Myosin antibody [BA-G5] (AB50967)

All lanes:

Western blot - Anti-heavy chain cardiac Myosin antibody [BA-G5] (ab50967) at 5 µg/mL

All lanes:

Heart (Mouse) Tissue Lysate at 10 µg

Secondary

All lanes:

IRDye 680 Conjugated Goat Anti-Mouse IgG (H+L) at 1/10000 dilution

Predicted band size: 223 kDa

Observed band size: 223 kDa

false

Unknown

Western blot - Anti-heavy chain cardiac Myosin antibody [BA-G5] (AB50967)

All lanes:

Western blot - Anti-heavy chain cardiac Myosin antibody [BA-G5] (ab50967) at 1 µg/mL

Lane 1:

Heart (Rat) Tissue Lysate at 10 µg

Lane 2:

Skeletal Muscle (Rat) Tissue Lysate at 10 µg

Secondary

All lanes:

Goat polyclonal to Mouse IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Predicted band size: 223 kDa

Observed band size: 223 kDa,48 kDa,95 kDa

true

Exposure time: 4min

不同偶联物与剂型 (1)

Carrier free

Anti-heavy chain cardiac Myosin antibody [BA-G5] - BSA and Azide free

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

BA-G5

亚型

IgG2b

不含载体蛋白

反应种属

Mouse, Rat

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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产品详情

Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 6.97% L-Arginine

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Heavy chain cardiac myosin also known as cardiac myosin heavy chain or MYH7 is a critical structural and functional component of cardiac muscle. It plays a significant role in the contractile mechanism of the heart by interacting with actin filaments. The known mass for the heavy chain cardiac myosin is approximately 223 kDa. This protein is mainly expressed in the cardiac muscle tissue where it contributes to the contractile apparatus that enables heart muscle contraction and relaxation essential for pumping blood throughout the body.

Biological function summary

Heavy chain cardiac myosin functions as part of the thick filament within the sarcomere which is the basic contractile unit of muscle cells. It forms a complex with other proteins such as myosin light chains and the protein titin to generate force through ATP hydrolysis. This interaction with actin within the sarcomere underlies muscle contraction with energy provided by ATP. Regulation of contraction and relaxation allows the heart to maintain rhythmic and forceful pumping critical for efficient blood circulation.

Pathways

Heavy chain cardiac myosin plays an integral role in the excitation-contraction coupling pathway. This pathway links the electrical signal of the heartbeat to the mechanical contraction of the heart muscles governed by a sequence of depolarization and subsequent release of calcium ions. Heavy chain cardiac myosin also interacts with related proteins such as tropomyosin and troponin which modulate the exposure of myosin binding sites on actin filaments and thereby regulate heart muscle contraction.

Mutations or abnormalities in the heavy chain cardiac myosin gene have strong associations with hypertrophic cardiomyopathy and dilated cardiomyopathy. These disorders result in changes to the structure and function of the heart potentially leading to heart failure. Heavy chain cardiac myosin mutations can further affect protein interactions like those with the aforementioned troponin complex altering contractility and impacting the heart's ability to pump efficiently. Researchers study these interactions to understand the mechanisms of cardiac diseases and to develop potential therapies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.

See full target information Myh7

其他靶点

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文献 (112)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 29:e70733 PubMed40682481

2025

Myeloid MyD88 Mediates Macrophage Infiltration and Activation in Ang II-Induced Cardiac Hypertrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Ke Lin,Na Yang,Chenghong Hu,Wu Luo,Ping Huang,Guang Liang,Yi Wang

Science advances 11:eadu8422 PubMed40561034

2025

Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3.

Applications

Unspecified application

Species

Unspecified reactive species

Bozhi Ye,Wante Lin,Yucheng Jiang,Zhaozheng Zheng,Yanhong Jin,Diyun Xu,Yingjie Liao,Zhihan Jia,Jiaji Chen,Gaojun Wu,Peiren Shan,Guang Liang

Cardiovascular therapeutics 2025:6813183 PubMed40225592

2025

Cysteine-Rich Protein 61 (CCN1) Deficiency Alleviated Cardiac Remodeling in 5/6 Nephrectomized Mice by Suppressing the MAPK Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yihan Zhao,Liang Gu,Yunxuan Chen,Yibei Lin,Jincheng Xing,Diyan Xu,Zhen Su,Zhouqing Huang

Scientific reports 15:7384 PubMed40025125

2025

Remodeling of the cardiac striatin interactome and its dynamics in the diabetic heart.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie Chacar,Wael Abdrabou,Cynthia Al Hageh,Liaqat Ali,Thenmozhi Venkatachalam,Pierre Zalloua,M-Saadeh Suleiman,Frank Christopher Howarth,Ali A Khraibi,Moni Nader

Cardiovascular toxicology 25:34-47 PubMed39521734

2024

Isoprenaline Inhibits Histone Demethylase LSD1 to Induce Cardiac Hypertrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Lili Wu,Bo Yang,Yingze Sun,Guanwei Fan,Lina Ma,Ying Ma,Xianjia Xiong,Hui Zhou,Huiping Wang,Ling Zhang,Bing Yang

Journal of cachexia, sarcopenia and muscle 15:2497-2508 PubMed39351645

2024

Tensile force impairs lip muscle regeneration under the regulation of interleukin-10.

Applications

Unspecified application

Species

Unspecified reactive species

Xu Cheng,Jinfeng Dou,Jinggui Li,Yixuan Huang,Bing Shi,Jingtao Li

Physiological reports 12:e70012 PubMed39169429

2024

Alterations in cardiac contractile and regulatory proteins contribute to age-related cardiac dysfunction in male rats.

Applications

Unspecified application

Species

Unspecified reactive species

Young Soo Han,Madona Pakkam,Matthew J Fogarty,Gary C Sieck,Frank V Brozovich

Redox biology 72:103154 PubMed38626575

2024

Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Zhong,Kangwei Wang,Yonghua Wang,Luya Wang,Sudan Wang,Weijian Huang,Zhuyin Jia,Shan-Shan Dai,Zhouqing Huang

Clinical epigenetics 16:42 PubMed38491513

2024

Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation.

Applications

Unspecified application

Species

Unspecified reactive species

Ke-Xin Li,Jia-Ru Li,Sheng-Jia Zuo,Xudong Li,Xian-Tong Chen,Pei-Yi Xiao,Hui-Tao Li,Ling Sun,Tao Qian,Hao-Min Zhang,Dongxing Zhu,Xi-Yong Yu,Guojun Chen,Xue-Yan Jiang

Cell chemical biology 30:1542-1556.e9 PubMed37714153

2023

Chemoproteomic strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration.

Applications

Unspecified application

Species

Unspecified reactive species

Dhanushika S K Kukulage,Maheeshi Yapa Abeywardana,Nadee N J Matarage Don,Ren-Ming Hu,Kyosuke Shishikura,Megan L Matthews,Young-Hoon Ahn

View all publications

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Anti-heavy chain cardiac Myosin 抗体 [BA-G5]