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重组RabMAb

重组Anti-HDAC6抗体[EPR6160] (ab133539)

Submit a review Submit a question References (2)
Western blot - Anti-HDAC6 antibody [EPR6160] (ab133539)
  • OI-RD Scanning - Anti-HDAC6 antibody [EPR6160] (ab133539)
  • Anti-HDAC6 antibody [EPR6160] (ab133539)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR6160] to HDAC6
  • Suitable for: WB
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

概述

  • 产品名称

    Anti-HDAC6抗体[EPR6160]
    参阅全部 HDAC6 一抗

  • 描述

    兔单克隆抗体[EPR6160] to HDAC6

  • 宿主

    Rabbit

  • 经测试应用

    适用于: WBmore details
    不适用于: Flow Cyt,ICC/IF,IHC-P or IP

  • 种属反应性

    与反应: Human

  • 免疫原

    Synthetic peptide within Human HDAC6 aa 1000-1100. The exact sequence is proprietary.

  • 阳性对照

    • 293T, HepG2, and K562 cell lysates.

  • 常规说明

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab133539于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
WB
1/1000 - 1/10000. Predicted molecular weight: 131 kDa.
说明
WB
1/1000 - 1/10000. Predicted molecular weight: 131 kDa.
应用说明
Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

靶标

  • 功能

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.

  • 序列相似性

    Belongs to the histone deacetylase family. HD type 2 subfamily.
    Contains 1 UBP-type zinc finger.

  • 翻译后修饰

    Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
    Sumoylated in vitro.

  • 细胞定位

    Nucleus. Cytoplasm. It is mainly cytoplasmic, where it is associated with microtubules.
  • Information by UniProt

  • 数据库链接

    • 别名

      • CPBHM antibody
      • FLJ16239 antibody
      • HD 6 antibody
      • HD6 antibody
      • HDAC 6 antibody
      • HDAC6 antibody
      • HDAC6_HUMAN antibody
      • Histone deacetylase 6 (HD6) antibody
      • Histone deacetylase 6 antibody
      • JM 21 antibody
      • JM21 antibody
      • KIAA0901 antibody
      • OTTHUMP00000032398 antibody
      • OTTHUMP00000197663 antibody
      • PPP1R90 antibody
      • Protein phosphatase 1 regulatory subunit 90 antibody
      see all

    图片

    • Western blot - Anti-HDAC6 antibody [EPR6160] (ab133539)
      Western blot - Anti-HDAC6 antibody [EPR6160] (ab133539)
      All lanes : Anti-HDAC6 antibody [EPR6160] (ab133539) at 1/1000 dilution

      Lane 1 : 293T cell lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : K562 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 131 kDa

    • OI-RD Scanning - Anti-HDAC6 antibody [EPR6160] (ab133539)
      OI-RD Scanning - Anti-HDAC6 antibody [EPR6160] (ab133539)
      Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD
    • Anti-HDAC6 antibody [EPR6160] (ab133539)
      Anti-HDAC6 antibody [EPR6160] (ab133539)

    文献 (2)

    发表研究结果有使用 ab133539？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab133539 被引用在 2 文献中.

    • Yin Z  et al. Overexpression of HDAC6 suppresses tumor cell proliferation and metastasis by inhibition of the canonical Wnt/ß-catenin signaling pathway in hepatocellular carcinoma. Oncol Lett 16:7082-7090 (2018). PubMed: 30546442
    • Ververis K & Karagiannis TC An atlas of histone deacetylase expression in breast cancer: fluorescence methodology for comparative semi-quantitative analysis. Am J Transl Res 4:24-43 (2012). WB ; Human . PubMed: 22347520

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