Anti-HDAC10抗体(ab18971)
Key features and details
- Rabbit polyclonal to HDAC10
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-HDAC10抗体
参阅全部 HDAC10 一抗 -
描述
兔多克隆抗体to HDAC10 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide corresponding to Human HDAC10 (N terminal).
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阳性对照
- Jurkat Cells, Mouse Intestine and Rat Brain for Western blot.
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常规说明
This product is manufactured by BioVision, an Abcam company and was previously called 3610 HDAC10 Antibody. 3610-100 is the same size as the 100 µg size of ab18971.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA -
Concentration information loading... -
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab18971于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
| 说明 |
|---|
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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功能
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. -
组织特异性
Ubiquitous. High expression in liver, spleen, pancreas and kidney. -
序列相似性
Belongs to the histone deacetylase family. HD type 2 subfamily. -
细胞定位
Cytoplasm. Nucleus. Excluded from the nucleoli. - Information by UniProt
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数据库链接
- Entrez Gene: 83933 Human
- Entrez Gene: 170787 Mouse
- Entrez Gene: 362981 Rat
- Omim: 608544 Human
- SwissProt: Q969S8 Human
- SwissProt: Q6P3E7 Mouse
- SwissProt: Q569C4 Rat
- Unigene: 26593 Human
see all -
别名
- DKFZP761B039 antibody
- HD 10 antibody
- HD10 antibody
see all
图片
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Western blot - Anti-HDAC10 antibody (ab18971)All lanes : Anti-HDAC10 antibody (ab18971) at 2.5 µg/ml
Lane 1 : Jurkat cell lysate (30ug)
Lane 2 : Mouse intestine lysate (30ug)
Lane 3 : Rat brain lysate (30ug)
Predicted band size: 71 kDa
Observed band size: 74 kDa why is the actual band size different from the predicted?
Additional bands at: 55 kDa. We are unsure as to the identity of these extra bands.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab18971 被引用在 2 文献中.
- Chi Z et al. Histone deacetylase 6 inhibitor tubastatin A attenuates angiotensin II-induced hypertension by preventing cystathionine ?-lyase protein degradation. Pharmacol Res 146:104281 (2019). PubMed: 31125601
- Liu J et al. Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells. J Transl Med 14:7 (2016). Human . PubMed: 26747087