AB400

Anti-hCG 抗体 [HCG1]

Name: hCG抗体[HCG1] (ab400)| Abcam中文官网
Brand: Abcam Limited
SKU: AB400
Price: 4829 CNY
Availability: InStock
Rating: 1 (1 reviews)

Anti-hCG antibody [HCG1]

(1 Review)

(9 Publications)

Mouse Monoclonal GLHA antibody. Suitable for ELISA, RIA, RID and reacts with Human samples. Cited in 9 publications.

查看别名

Glycoprotein hormones alpha chain, Anterior pituitary glycoprotein hormones common subunit alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, Follicle-stimulating hormone alpha chain, Follitropin alpha chain, Luteinizing hormone alpha chain, Lutropin alpha chain, Thyroid-stimulating hormone alpha chain, Thyrotropin alpha chain, CG-alpha, FSH-alpha, LSH-alpha, TSH-alpha, CGA

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

HCG1

亚型

IgG1

轻链类型

unknown

不含载体蛋白

反应种属

Human

应用

ELISA, RID, RIA

applications

特异性

hCG specifically recognises human chorionic gonadotropin. Its affinity for the free beta-chain is slightly greater than its affinity for the whole molecule.hCG - 100% hCG (beta) - 125% hCG (alpha) - <1% hLH - <1% hTSH - <0.05% hFSH - <0.1% Affinity constant: 5x10⁹ l/mol HCG.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"}, "RID" : {"fullname" : "Radial Immunodiffusion", "shortname":"RID"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "", "RID-species-checked": "guaranteed", "RID-species-dilution-info": "", "RID-species-notes": "" } } }

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产品详情

Association Constant: hCG: 4.0 x 10⁶ and hCGbeta: 1.6 x 10⁶
Dissociation Constant: hCG: 1.4 x 10^-4 and hCGbeta: 3.6 x 10^-4
Affinity Constant hCG: KA = 2.9 x 10¹⁰ 1/M; KD = 3.4 x 10^-11 M (= 0.03 nM)
Affinity Constant hCGbeta: KA = 4.4 x 10⁹ 1/M; KD = 2.3 x 10^-10 M (= 0.23 nM)
Determination method: SPR analysis
Antigen: hCG; hCG-beta

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

Preservative: 0.1% Sodium azide Constituents: 0.9% Sodium chloride

运输条件

Blue Ice

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed of two subunits alpha and beta. The beta subunit confers its specific biological activity. Its molecular weight ranges around 36.7 kDa. hCG is produced in the placenta during pregnancy and is also expressed in pituitary cells. Known alternatively as the pregnancy hormone hCG plays a critical role in maintaining the luteal function during the early stages of pregnancy.

Biological function summary

HCG regulates several functions related to reproduction. It supports the corpus luteum in ovaries to secrete progesterone during early pregnancy contributing to the uterine lining's maintenance. Moreover hCG can interact with the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) indicating its involvement in broader reproductive functions. Not as well known hCG may exist in various forms such as hCG intact influencing certain biological pathways differently.

Pathways

Scientists study hCG's role in reproductive signaling and gonadotropin pathways. It interacts closely with luteinizing hormone (LH) with substantial overlap in their pathway functions impacting reproductive health and fertility cycles. hCG's activation of specific receptors like LHCGR plays a role in these pathways connecting it to various fertility-related responses in the human body.

HCG levels can be an indicative marker for certain conditions. Elevated hCG levels may signal trophoblastic diseases such as molar pregnancy or gestational trophoblastic neoplasia. Its abnormal expression might also indicate testicular cancer where it acts as a tumor marker. Both conditions relate to hCG through its shared glycoprotein structure with other hormones like thyroid-stimulating hormone (TSH) which links the hormone to broader endocrine disorder research.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

See full target information CGA

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文献 (9)

Recent publications for all applications. Explore the full list and refine your search

The Korean journal of internal medicine 36:S180-S195 PubMed32942841

2020

L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction.

Applications

Unspecified application

Species

Unspecified reactive species

Hai Yan Zhao,Hui Ying Li,Jian Jin,Ji Zhe Jin,Long Ye Zhang,Mei Ying Xuan,Xue Mei Jin,Yu Ji Jiang,Hai Lan Zheng,Ying Shun Jin,Yong Jie Jin,Bum Soon Choi,Chul Woo Yang,Shang Guo Piao,Can Li

Nature communications 11:1395 PubMed32170083

2020

An engineered oncolytic virus expressing PD-L1 inhibitors activates tumor neoantigen-specific T cell responses.

Applications

Unspecified application

Species

Unspecified reactive species

Guan Wang,Xi Kang,Katherine S Chen,Tiffany Jehng,Lindsey Jones,Jie Chen,Xue F Huang,Si-Yi Chen

Saudi journal of biological sciences 26:2074-2078 PubMed31889797

2019

Anti-CD47 antibody eliminates bone tumors in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Shiqiang Fang,Hainan Yin,Zhen Song,Ruixin Li,Xuesheng Xie,Zengquan Gu

Analytical and bioanalytical chemistry 411:6837-6845 PubMed31471682

2019

New photothermal immunoassay of human chorionic gonadotropin using Prussian blue nanoparticle-based photothermal conversion.

Applications

Unspecified application

Species

Unspecified reactive species

Guolin Hong,Dongdong Zhang,Yinghao He,Yuanyuan Yang,Ping Chen,Huijing Yang,Zhiyang Zhou,Yinhuan Liu,Yan Wang

Diagnostics (Basel, Switzerland) 8: PubMed29316718

2018

Label-Free Sensors Based on Graphene Field-Effect Transistors for the Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker.

Applications

Unspecified application

Species

Unspecified reactive species

Carrie Haslam,Samar Damiati,Toby Whitley,Paul Davey,Emmanuel Ifeachor,Shakil A Awan

Nature biotechnology 20:1261-4 PubMed12426580

2002

BMP4 initiates human embryonic stem cell differentiation to trophoblast.

Applications

Unspecified application

Species

Unspecified reactive species

Ren-He Xu,Xin Chen,Dong S Li,Rui Li,Gregory C Addicks,Clay Glennon,Thomas P Zwaka,James A Thomson

Analytical biochemistry 206:168-71 PubMed1456429

1992

Latex-based thin-layer immunoaffinity chromatography for quantitation of protein analytes.

Applications

Unspecified application

Species

Unspecified reactive species

S Birnbaum,C Udén,C G Magnusson,S Nilsson

Clinical chemistry 29:60-4 PubMed6848283

1983

Time-resolved fluoroimmunoassay of human choriogonadotropin.

Applications

Unspecified application

Species

Unspecified reactive species

K Pettersson,H Siitari,I Hemmilä,E Soini,T Lövgren,V Hänninen,P Tanner,U H Stenman

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 29:864-5 PubMed6167612

1981

The use of monoclonal antibodies against human chorionic gonadotropin for immunoperoxidase staining of normal placenta, pituitary gland, and pituitary adenomas.

Applications

Unspecified application

Species

Unspecified reactive species

T Wahlström,U H Stenman,C Lundqvist,P Tanner,J Schröder,M Seppälä

View all publications

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