AB89241

Anti-HBEGF/DTR抗体[MM0324-3R44]

Name: HBEGF/DTR抗体[MM0324-3R44] (ab89241)| Abcam中文官网
Brand: Abcam Limited
SKU: AB89241
Price: 4752 CNY
Availability: InStock

Anti-HBEGF/DTR antibody [MM0324-3R44]

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(2 Publications)

Mouse Monoclonal HBEGF/DTR antibody. Suitable for WB, FuncS (Neut/Block) and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HBEGF.

查看别名

DTR, DTS, HEGFL, HBEGF, Proheparin-binding EGF-like growth factor

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

MM0324-3R44

亚型

IgG2

不含载体蛋白

反应种属

Human

应用

FuncS (Neut/Block), WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human HBEGF.

Q99075

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

纯化说明

The IgG fraction of culture supernatant was purified by Protein G affinity chromatography.

存储溶液

Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

HBEGF also known as Heparin-binding EGF-like growth factor or Diphtheria Toxin Receptor (DTR) is a growth factor that binds to EGF receptors with its mass approximately 20 kilodaltons. It is a member of the EGF family. Cells secrete HBEGF and it is expressed in many tissues including the heart kidney and lungs. Its expression often increases during proliferation and differentiation making it an important player in tissue growth and repair.

Biological function summary

HBEGF functions as a mitogen and chemotactic agent which means it stimulates cell division and attracts cells to migrate. As part of the EGF family HBEGF activates the EGFR (epidermal growth factor receptor) signaling cascade. This signaling is essential for processes such as wound healing and development. HBEGF also forms complexes with other ligands and receptors enhancing its biological activity in tissues.

Pathways

HBEGF plays a role in the MAPK/ERK signaling pathway and the PI3K/AKT pathway. Both pathways are significant for regulating cell growth survival and differentiation. HBEGF interacts with other proteins like Ras and PI3K in these pathways. By activating these pathways HBEGF influences cellular responses critical for normal physiological processes and recovery mechanisms in cells.

HBEGF has connections with cancer and cardiovascular diseases. Aberrant HBEGF signaling can promote oncogenic processes in cancer relating it to proteins such as HER2 which also engage in similar pathways. In cardiovascular diseases HBEGF overexpression can contribute to smooth muscle cell proliferation an important event in atherosclerosis linking it to other growth factors involved in vascular biology.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

See full target information HBEGF

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cell research 30:779-793 PubMed32296111

2020

s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide.

Applications

Unspecified application

Species

Unspecified reactive species

Peihua Luo,Hao Yan,Xueqin Chen,Ying Zhang,Ziying Zhao,Ji Cao,Yi Zhu,Jiangxia Du,Zhifei Xu,Xiaochen Zhang,Su Zeng,Bo Yang,Shenglin Ma,Qiaojun He

International journal of biological sciences 15:493-506 PubMed30745837

2019

CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17.

Applications

Unspecified application

Species

Unspecified reactive species