AB218019

Anti-HBEGF/DTR 抗体

Name: HBEGF/DTR抗体 (ab218019)| Abcam中文官网
Brand: Abcam Limited
SKU: AB218019
Price: 4748 CNY
Availability: InStock

Anti-HBEGF/DTR antibody

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(3 Publications)

Rabbit Polyclonal HBEGF/DTR antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human HBEGF aa 50-150 conjugated to Keyhole Limpet Haemocyanin.

查看别名

DTR, DTS, HEGFL, HBEGF, Proheparin-binding EGF-like growth factor

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HBEGF/DTR antibody (AB218019)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HBEGF/DTR antibody (AB218019)

Immunohistochemical analysis of formalin fixed, paraffin embedded rat kidney tissue labeling HBEGF/DTR with ab218019 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HBEGF/DTR antibody (AB218019)

Immunohistochemical analysis of formalin fixed, paraffin embedded rat heart tissue labeling HBEGF/DTR with ab218019 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat

应用

IHC-P

applications

免疫原

Synthetic Peptide within Human HBEGF aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q99075

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

HBEGF also known as Heparin-binding EGF-like growth factor or Diphtheria Toxin Receptor (DTR) is a growth factor that binds to EGF receptors with its mass approximately 20 kilodaltons. It is a member of the EGF family. Cells secrete HBEGF and it is expressed in many tissues including the heart kidney and lungs. Its expression often increases during proliferation and differentiation making it an important player in tissue growth and repair.

Biological function summary

HBEGF functions as a mitogen and chemotactic agent which means it stimulates cell division and attracts cells to migrate. As part of the EGF family HBEGF activates the EGFR (epidermal growth factor receptor) signaling cascade. This signaling is essential for processes such as wound healing and development. HBEGF also forms complexes with other ligands and receptors enhancing its biological activity in tissues.

Pathways

HBEGF plays a role in the MAPK/ERK signaling pathway and the PI3K/AKT pathway. Both pathways are significant for regulating cell growth survival and differentiation. HBEGF interacts with other proteins like Ras and PI3K in these pathways. By activating these pathways HBEGF influences cellular responses critical for normal physiological processes and recovery mechanisms in cells.

HBEGF has connections with cancer and cardiovascular diseases. Aberrant HBEGF signaling can promote oncogenic processes in cancer relating it to proteins such as HER2 which also engage in similar pathways. In cardiovascular diseases HBEGF overexpression can contribute to smooth muscle cell proliferation an important event in atherosclerosis linking it to other growth factors involved in vascular biology.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

See full target information HBEGF

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of gastrointestinal oncology 15:1035-1049 PubMed38989423

2024

B7-H3 enhances colorectal cancer progression by regulating HB-EGF via HIF-1α.

Applications

Unspecified application

Species

Unspecified reactive species

Chenrui Hu,Shengjia Wang,Jin Wang,Xiaokang Ruan,Linwei Wu,Zhe Zhang,Xuefeng Wang,Jianglei Zhang,Yonghao Liu,Yao Li,Xin Zhao

Gynecologic and obstetric investigation 90:42-54 PubMed38934184

2024

METTL14 Promotes Proliferation, Migration, and Invasion in Endometriotic Stromal Cell Growth by Activating the ZEB1/MEK/ERK Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xuan Lv,Fang Li

Diagnostic pathology 14:85 PubMed31370844

2019

Alpha fetoprotein (AFP) participates in the build up of hematopoietic cells in the early embryonic stage: an abortion case observation.

Applications

Unspecified application

Species

Unspecified reactive species

Jianhong An,Yufeng Zhang,Jiao Luo,Hong Shen

View all publications

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Anti-HBEGF/DTR 抗体

Anti-HBEGF/DTR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HBEGF/DTR antibody (AB218019)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HBEGF/DTR antibody (AB218019)