Anti-HAX1抗体(ab78939)
Key features and details
- Rabbit polyclonal to HAX1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-HAX1抗体
参阅全部 HAX1 一抗 -
描述
兔多克隆抗体to HAX1 -
宿主
Rabbit -
特异性
At least four isoforms of HAX1 are known to exist. ab78939 is expected to recognize the longest isoform (HAX1a) as well as the shortest. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human HAX1. A 15 amino acid synthetic peptide near the amino terminus of human HAX1. The immunogen is located within the first 50 amino acids of Hax1a.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
ab78939 was purified by affinity chromatography via a peptide column -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab78939于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 32 kDa.
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| 说明 |
|---|
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 32 kDa. |
靶标
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功能
Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools. -
组织特异性
Ubiquitous. Up-regulated in oral cancers. -
疾病相关
Defects in HAX1 are the cause of neutropenia severe congenital autosomal recessive type 3 (SCN3) [MIM:610738]; also known as Kostmann disease. A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. Some patients affected by severe congenital neutropenia type 3 have neurological manifestations such as psychomotor retardation and seizures. Note=The clinical phenotype due to HAX1 deficiency appears to depend on the localization of the mutations and their influence on the transcript variants. Mutations affecting exclusively isoform 1 are associated with isolated congenital neutropenia, whereas mutations affecting both isoform 1 and isoform 5 are associated with additional neurologic symptoms. -
序列相似性
Belongs to the HAX1 family. -
翻译后修饰
Proteolytically cleaved by caspase-3 during apoptosis. -
细胞定位
Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Sarcoplasmic reticulum. - Information by UniProt
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数据库链接
- Entrez Gene: 10456 Human
- Omim: 605998 Human
- SwissProt: O00165 Human
- Unigene: 199625 Human
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别名
- FLJ17042 antibody
- FLJ18492 antibody
- FLJ93803 antibody
see all
图片
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Western blot - Anti-HAX1 antibody (ab78939)Lane 1 : Anti-HAX1 antibody (ab78939) at 1 µg/ml
Lane 2 : Anti-HAX1 antibody (ab78939) at 2 µg/ml
All lanes : Human brain tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 32 kDa
Observed band size: 36 kDa why is the actual band size different from the predicted?
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab78939 被引用在 3 文献中.
- Chen Y et al. Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages. J Exp Clin Cancer Res 41:1 (2022). PubMed: 34980222
- Zha Z & Li J MicroRNA-125a-5p regulates liver cancer cell growth, migration and invasion and EMT by targeting HAX1. Int J Mol Med 46:1849-1861 (2020). PubMed: 33000203
- Rivers-Auty J et al. Redefining the ancestral origins of the interleukin-1 superfamily. Nat Commun 9:1156 (2018). PubMed: 29559685